Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.

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http://www.wikidata.org/entity/Q30437231
Interaction of integrin β4 with S1P receptors in S1P- and HGF-induced endothelial barrier enhancementFTY720 story. Its discovery and the following accelerated development of sphingosine 1-phosphate receptor agonists as immunomodulators based on reverse pharmacologyIntegrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactionsDesign, synthesis and biological activity of sphingosine kinase 2 selective inhibitors.Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitorsSynthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs.Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist.Pulmonary endothelial cell barrier enhancement by novel FTY720 analogs: methoxy-FTY720, fluoro-FTY720, and β-glucuronide-FTY720.FTY720 (fingolimod) in renal transplantation.Current perspectives on FTY720.Sphingosine-1-phosphate, FTY720, and sphingosine-1-phosphate receptors in the pathobiology of acute lung injury.Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).Promiscuous drugs as therapeutics for chemokine receptors.Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.Sphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.
P2860

Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.

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http://www.wikidata.org/entity/Q30437231
description
2005 nî lūn-bûn
@nan
2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@ast
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@en
type
label
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@ast
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@en
prefLabel
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@ast
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@en
P1433
P1476
P2093
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Synthesis of 4(5)-phenylimidaz ...... potent S1P1 receptor agonists.
@en
P2093
P304
P31
P356
10.1016/J.BMCL.2005.05.097
P407
P433
P478
P577
P698