Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.
about
The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retroviruspp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions.An SH3 domain-containing GTPase-activating protein for Rho and Cdc42 associates with focal adhesion kinaseIdentification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions.Overexpression of c-src enhances beta-adrenergic-induced cAMP accumulationSingle missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2BStable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK.En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase.Regulated expression of focal adhesion kinase-related nonkinase, the autonomously expressed C-terminal domain of focal adhesion kinase.Mutations within the 5' half of the avian retrovirus MC29 v-myc gene alter or abolish transformation of chicken embryo fibroblasts and macrophages.Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.Neoplastic transformation of normal and carcinogen-induced preneoplastic Syrian hamster embryo cells by the v-src oncogene.Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteinspp60c-src tyrosine kinase, myristylation, and modulatory domains are required for enhanced mitogenic responsiveness to epidermal growth factor seen in cells overexpressing c-srcTransformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stabilityRous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.The protooncogene c-sea encodes a transmembrane protein-tyrosine kinase related to the Met/hepatocyte growth factor/scatter factor receptorIntegrin-dependent activation of the p70 ribosomal S6 kinase signaling pathway.A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane.Autophosphorylation is required for high kinase activity and efficient transformation ability of proteins encoded by host range alleles of v-src.Structural differences between repressed and derepressed forms of p60c-srcLinker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutantsLocalization of the v-rel protein in reticuloendotheliosis virus strain T-transformed lymphoid cellsNeither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein.Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinasesNucleotide sequence of the yeast regulatory gene STE7 predicts a protein homologous to protein kinases.Complementary roles of the Cek1 and Cek2 MAP kinases in Candida albicans cell-wall biogenesis.Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.Localization of temperature-sensitive transformation mutations and back mutations in the Rous sarcoma virus src gene.A single point mutation has pleiotropic effects on pp60v-src function.Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe.Complete purification of the pseudorabies virus protein kinase.
P2860
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P2860
Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.
description
1984 nî lūn-bûn
@nan
1984 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1984 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1984年の論文
@ja
1984年論文
@yue
1984年論文
@zh-hant
1984年論文
@zh-hk
1984年論文
@zh-mo
1984年論文
@zh-tw
1984年论文
@wuu
name
Amino acid alterations within ...... osine protein kinase activity.
@ast
Amino acid alterations within ...... osine protein kinase activity.
@en
type
label
Amino acid alterations within ...... osine protein kinase activity.
@ast
Amino acid alterations within ...... osine protein kinase activity.
@en
prefLabel
Amino acid alterations within ...... osine protein kinase activity.
@ast
Amino acid alterations within ...... osine protein kinase activity.
@en
P2860
P356
P1476
Amino acid alterations within ...... osine protein kinase activity.
@en
P2093
D L Bryant
J T Parsons
P2860
P304
P356
10.1128/MCB.4.5.862
P407
P577
1984-05-01T00:00:00Z