Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases
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Closing in on the biological functions of Fps/Fes and FerHierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptorThe SRC-associated protein CUB Domain-Containing Protein-1 regulates adhesion and motilitySH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathwayG protein-coupled chemoattractant receptors regulate Lyn tyrosine kinase.Shc adapter protein signaling complexesEpidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase.A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate.SU6656, a selective src family kinase inhibitor, used to probe growth factor signalingThe heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytesA mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brainIdentification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimeraShc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cellsGRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulationTyrosine phosphorylation sites at amino acids 239 and 240 of Shc are involved in epidermal growth factor-induced mitogenic signaling that is distinct from Ras/mitogen-activated protein kinase activationTyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOSTwo adaptor proteins differentially modulate the phosphorylation and biophysics of Kv1.3 ion channel by SRC kinaseIdentification of Grb10 as a direct substrate for members of the Src tyrosine kinase familyNon-redundant signal transduction of interleukin-6-type cytokines. The adapter protein Shc is specifically recruited to rhe oncostatin M receptorA yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partnersDifferential actions of p60c-Src and Lck kinases on the Ras regulators p120-GAP and GDP/GTP exchange factor CDC25MmN-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signalingT cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway activationIdentification of a novel 135-kDa Grb2-binding protein in osteoclastsThe Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell signalingCloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cellsStimulation of growth factor receptor signal transduction by activation of voltage-sensitive calcium channelsDistinct tyrosine autophosphorylation sites negatively and positively modulate neu-mediated transformationMutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblastsT-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiationInteraction of Shc with Grb2 regulates association of Grb2 with mSOSA role for Src in signal relay by the platelet-derived growth factor alpha receptorCD16-mediated p21ras activation is associated with Shc and p36 tyrosine phosphorylation and their binding with Grb2 in human natural killer cells.c-Cbl is inducibly tyrosine-phosphorylated by epidermal growth factor stimulation in fibroblasts, and constitutively tyrosine-phosphorylated and associated with v-Src in v-src-transformed fibroblasts.Cooperation of Src homology domains in the regulated binding of phosphatidylinositol 3-kinase. A role for the Src homology 2 domain.Muscarinic receptors transform NIH 3T3 cells through a Ras-dependent signalling pathway inhibited by the Ras-GTPase-activating protein SH3 domain.Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-srcSignal transduction in mammary tumorigenesis: a transgenic perspective.Src and Ras are involved in separate pathways in epithelial cell scattering.G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein
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P2860
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on October 1992
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Shc proteins are phosphorylate ...... v-Fps protein-tyrosine kinases
@en
Shc proteins are phosphorylate ...... -Fps protein-tyrosine kinases.
@nl
type
label
Shc proteins are phosphorylate ...... v-Fps protein-tyrosine kinases
@en
Shc proteins are phosphorylate ...... -Fps protein-tyrosine kinases.
@nl
prefLabel
Shc proteins are phosphorylate ...... v-Fps protein-tyrosine kinases
@en
Shc proteins are phosphorylate ...... -Fps protein-tyrosine kinases.
@nl
P2093
P2860
P356
P1476
Shc proteins are phosphorylate ...... v-Fps protein-tyrosine kinases
@en
P2093
P2860
P304
P356
10.1073/PNAS.89.19.8869
P407
P577
1992-10-01T00:00:00Z