Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
about
A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1Is HIV-1 RNA dimerization a prerequisite for packaging? Yes, no, probably?Emerging clinical applications of RNAIn vivo selection of tumor-targeting RNA motifs.A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme librariesFactors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.Artificial regulation of gene expression in Escherichia coli by RNase P.Monitoring retroviral RNA dimerization in vivo via hammerhead ribozyme cleavage.Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cellsEvaluating group I intron catalytic efficiency in mammalian cells.Gene therapy for infectious diseasesChimeric snRNA molecules carrying antisense sequences against the splice junctions of exon 51 of the dystrophin pre-mRNA induce exon skipping and restoration of a dystrophin synthesis in Delta 48-50 DMD cellsEffective ribozyme delivery in plant cells.Gene therapy for HIV.Current status of ribozymes as gene therapy agents for cancer.The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymesRNA-based gene therapy for HIV infection.Effects of variations in length of hammerhead ribozyme antisense arms upon the cleavage of longer RNA substrates.Co-packaging of sense and antisense RNAs: a novel strategy for blocking HIV-1 replication.Hammerhead ribozymes for target validation.Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA.Antiviral therapy for human immunodeficiency virus infectionsRNA secondary structure and binding sites for gag gene products in the 5' packaging signal of human immunodeficiency virus type 1.RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNAA small nucleolar RNA:ribozyme hybrid cleaves a nucleolar RNA target in vivo with near-perfect efficiencyControlled and localized genetic manipulation in the brain.Proximity-dependent and proximity-independent trans-splicing in mammalian cellsSelection of efficient cleavage sites in target RNAs by using a ribozyme expression library.Ribozyme-mediated high resistance against potato spindle tuber viroid in transgenic potatoes.tRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells.A conditionally replicating HIV-1 vector interferes with wild-type HIV-1 replication and spread.U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus.The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.In vitro selection of external guide sequences for directing RNase P-mediated inhibition of viral gene expression.Ribonuclease H attack of leukaemic fused transcripts AML1-MTG8 (ETO) by DNA/RNA chimeric hammerhead ribozymes.Human immunodeficiency virus type-1 reverse transcription can be inhibited in vitro by oligonucleotides that target both natural and synthetic tRNA primers.RNase P ribozymes selected in vitro to cleave a viral mRNA effectively inhibit its expression in cell culture.Intracellular efficacy of tumor-targeting group I intron-based trans-splicing ribozyme.Tailing cDNAs with terminal deoxynucleotidyl transferase in RT-PCR assays to identify ribozyme cleavage products.
P2860
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P2860
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
description
1993 nî lūn-bûn
@nan
1993 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@ast
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@en
type
label
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@ast
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@en
prefLabel
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@ast
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@en
P356
P1433
P1476
Tethering ribozymes to a retroviral packaging signal for destruction of viral RNA.
@en
P2093
P304
P356
10.1126/SCIENCE.8248806
P407
P577
1993-12-01T00:00:00Z