The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.
about
The snoRNA box C/D motif directs nucleolar targeting and also couples snoRNA synthesis and localization.Targeting a KH-domain protein with RNA decoys.Co-expression of anti-NFkappaB RNA aptamers and siRNAs leads to maximal suppression of NFkappaB activity in mammalian cells.Engineered external guide sequences are highly effective in inducing RNase P for inhibition of gene expression and replication of human cytomegalovirusInvestigating a New Generation of Ribozymes in Order to Target HCVRNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cellsHIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell cultureBcl2-low-expressing MCF7 cells undergo necrosis rather than apoptosis upon staurosporine treatmentA functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme librariesSustained Inhibition of HBV Replication In Vivo after Systemic Injection of AAVs Encoding Artificial Antiviral Primary MicroRNAs.Factors governing the activity in vivo of ribozymes transcribed by RNA polymerase III.Dissecting human cytomegalovirus gene function and capsid maturation by ribozyme targeting and electron cryomicroscopyEngineered RNase P ribozymes effectively inhibit human cytomegalovirus gene expression and replicationSalmonella-mediated delivery of RNase P-based ribozymes for inhibition of viral gene expression and replication in human cells.Significantly higher activity of a cytoplasmic hammerhead ribozyme than a corresponding nuclear counterpart: engineered tRNAs with an extended 3' end can be exported efficiently and specifically to the cytoplasm in mammalian cellsReduction of target gene expression by a modified U1 snRNA.Effective inhibition of herpes simplex virus 1 gene expression and growth by engineered RNase P ribozyme.Chimeric snRNA molecules carrying antisense sequences against the splice junctions of exon 51 of the dystrophin pre-mRNA induce exon skipping and restoration of a dystrophin synthesis in Delta 48-50 DMD cellsDeriving four functional anti-HIV siRNAs from a single Pol III-generated transcript comprising two adjacent long hairpin RNA precursors.Intracellular expression of engineered RNase P ribozymes effectively blocks gene expression and replication of human cytomegalovirusEngineered external guide sequences effectively block viral gene expression and replication in cultured cells.Short hairpin type of dsRNAs that are controlled by tRNA(Val) promoter significantly induce RNAi-mediated gene silencing in the cytoplasm of human cells.Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme.Oral delivery of RNase P ribozymes by Salmonella inhibits viral infection in mice.Variables and strategies in development of therapeutic post-transcriptional gene silencing agentsEffective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli.RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNADevelopment of lead hammerhead ribozyme candidates against human rod opsin mRNA for retinal degeneration therapy.Impact of sustained RNAi-mediated suppression of cellular cofactor Tat-SF1 on HIV-1 replication in CD4+ T cells.Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model.RNase P-associated external guide sequence effectively reduces the expression of human CC-chemokine receptor 5 and inhibits the infection of human immunodeficiency virus 1Effective inhibition in animals of viral pathogenesis by a ribozyme derived from RNase P catalytic RNAtRNAVal-heterodimeric maxizymes with high potential as geneinactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells.Direct selection for ribozyme cleavage activity in cellsA significant increase of RNAi efficiency in human cells by the CMV enhancer with a tRNAlys promoter.Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the RatEndogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1.Ribonuclease P-mediated inhibition of human cytomegalovirus gene expression and replication induced by engineered external guide sequences.Inhibition of luciferase expression by synthetic hammerhead ribozymes and their cellular uptakePromoter choice affects the potency of HIV-1 specific RNA interference.
P2860
Q22066055-39B8C9E9-FE77-4912-BA48-0414E988524AQ24540133-85382994-3701-4290-909F-C204CE60466FQ25255937-6CFA3E95-E301-4AC9-B6F4-4AD8CC2B1282Q25257324-7848E9CE-4414-4B4B-8B55-D798536D7044Q27491032-60D82C7A-3BFC-44F0-B83A-DC7CD75D3EC2Q30476196-7D256B8D-7624-4BB1-AA4D-CD7C00A51EAFQ30953558-BC8F4BB2-AD17-4B90-9F6F-902C680ED04AQ31038879-14971374-6E9E-4B14-BF12-CBA0BA3F2F1DQ33184078-A2306001-2049-4F7D-BBBA-2FBB680441A1Q33635361-41D093FC-B6D8-441B-9C40-9831F5B8375AQ33652811-3107B3E2-BF94-41AF-8160-C3913E201CEAQ33780745-50A41072-06D8-4215-8024-DF11F7F0E3F9Q33820722-AA2990B4-9B51-4733-8BF7-9B9596185957Q33842038-50116AC4-D8BB-4CBE-8AF0-2FD0D2739B67Q33939807-2CD24FBC-400A-44C1-93F8-8FE4589E9F26Q33967927-425D9FD2-5044-40F1-84F9-D34F64E7CE54Q34004603-112C1A62-83F0-4DE2-9E49-B10965E235F0Q34035676-89D67BC1-EDD6-4822-AEEC-7A36E63E6460Q34246650-53896CF1-2501-4017-8EA3-D0EF3FAB2DFDQ34366924-32194029-B8F6-493F-81F8-41F8460A07AAQ34452558-F63073A8-70AE-44AF-8BA5-11343A767A34Q34460403-FCFE5D08-ED33-4C3B-9E68-9F8D1A26D558Q34540271-C60177DD-A3BF-4447-8A2D-8BB79B38C984Q34602827-671CAE27-F991-4D28-BFBA-5ECC9EA8A686Q35110219-D4ED9739-A2A6-4B5E-8229-91E6024A4743Q35749594-5542BD29-940D-4F8E-B90C-A5560DA63E8AQ35886262-F9F85008-B9A6-421E-9D58-85EB2552215CQ36073816-FDF92A89-74DD-43A8-AD35-E93EF32EB098Q36437368-6FEC3396-57FC-43B0-B65C-A4D7B49CB1F9Q36555327-BBBBD831-9FE2-4B00-A206-21FBA93CBB9DQ36665338-6C4AF135-3844-4F1A-B8CD-4C4CDCAAC642Q36825203-F0197C4F-DC8E-466C-9285-7A4E57CA4084Q37162170-7710F0F8-163B-4BD4-9F4E-74F7DC545AA6Q37393572-BD6D2766-0FFA-42BF-BD78-830A9CF2AD2AQ37398085-E1252146-0756-4610-9B62-9FEBAFAD3D3AQ37672325-512B447C-234A-460D-9E62-6EE025877DF3Q38362885-87DD0948-649C-4587-BDBB-C9E841353E4BQ39270183-7275FC9A-ED52-460D-95CA-7F4CAA71B5ECQ39728591-9A183ECD-C2F6-4E0B-8E37-96BD8692A93EQ39959002-52D5BB12-732D-469E-BF69-F2E13EEBED51
P2860
The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization.
description
1997 nî lūn-bûn
@nan
1997 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1997 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
name
The expression cassette determ ...... ir intracellular localization.
@ast
The expression cassette determ ...... ir intracellular localization.
@en
The expression cassette determ ...... ir intracellular localization.
@nl
type
label
The expression cassette determ ...... ir intracellular localization.
@ast
The expression cassette determ ...... ir intracellular localization.
@en
The expression cassette determ ...... ir intracellular localization.
@nl
prefLabel
The expression cassette determ ...... ir intracellular localization.
@ast
The expression cassette determ ...... ir intracellular localization.
@en
The expression cassette determ ...... ir intracellular localization.
@nl
P2093
P2860
P1433
P1476
The expression cassette determ ...... eir intracellular localization
@en
P2093
C Carbonnelle
D Castanotto
E Bertrand
S Chatterjee
P2860
P407
P577
1997-01-01T00:00:00Z