Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. - Wikidata - awgldk - TriplyDB

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.

http://www.wikidata.org/entity/Q30476942

about

SCN4B-encoded sodium channel beta4 subunit in congenital long-QT syndrome Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain Scn3b knockout mice exhibit abnormal ventricular electrophysiological properties Mechanisms of sodium channel clustering and its influence on axonal impulse conduction Trafficking regulates the subcellular distribution of voltage-gated sodium channels in primary sensory neurons Channelopathies from mutations in the cardiac sodium channel protein complex Trafficking mechanisms underlying neuronal voltage-gated ion channel localization at the axon initial segment Homeostasis or channelopathy? Acquired cell type-specific ion channel changes in temporal lobe epilepsy and their antiepileptic potential Sodium channel β subunits: emerging targets in channelopathies Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ankyrin Nodes of Ranvier and axon initial segments are ankyrin G-dependent domains that assemble by distinct mechanisms Scn3b knockout mice exhibit abnormal sino-atrial and cardiac conduction properties Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels.Is there more than one way to skin a newt? Convergent toxin resistance in snakes is not due to a common genetic mechanism.The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels.Molecular cloning and analysis of zebrafish voltage-gated sodium channel beta subunit genes: implications for the evolution of electrical signaling in vertebrates.Axonal Membranes and Their Domains: Assembly and Function of the Axon Initial Segment and Node of Ranvier.Curing epilepsy: progress and future directions Inherited disorders of voltage-gated sodium channels.More than a pore: ion channel signaling complexes Reduced sodium channel Na(v)1.1 levels in BACE1-null mice Na Channel β Subunits: Overachievers of the Ion Channel Family.Your Father and Grandfather's Atrial Fibrillation: A Review of the Genetics of the Most Common Pathologic Cardiac Dysrhythmia Subunit dependence of Na channel slow inactivation and open channel block in cerebellar neurons MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancers Sodium channel mutations in epilepsy and other neurological disorders.Neonatal epilepsy syndromes and GEFS+: mechanistic considerations.Identification of the cysteine residue responsible for disulfide linkage of Na+ channel α and β2 subunits Na(+) current in human ventricle: implications for sodium loading and homeostasis.The immunoglobulin domain of the sodium channel β3 subunit contains a surface-localized disulfide bond that is required for homophilic binding Conduction block in PMP22 deficiency.Loss of Na+ channel beta2 subunits is neuroprotective in a mouse model of multiple sclerosis.BACE1 regulates voltage-gated sodium channels and neuronal activity.Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms.The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential.Electrophysiology and beyond: multiple roles of Na+ channel β subunits in development and disease.Alzheimer's secretases regulate voltage-gated sodium channels.Redox control of cardiac excitability.

P2860

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P2860

Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits.

http://www.wikidata.org/entity/Q30476942

description

2002 nî lūn-bûn

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2002 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

Reduced sodium channel density ...... odium channel beta 2-subunits.

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Reduced sodium channel density ...... odium channel beta 2-subunits.

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Reduced sodium channel density ...... odium channel beta 2-subunits.

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Reduced sodium channel density ...... odium channel beta 2-subunits.

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Reduced sodium channel density ...... odium channel beta 2-subunits.

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Proceedings of the National Academy of Sciences of the United States of America

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Reduced sodium channel density ...... odium channel beta 2-subunits.

@en

P2093

Angus Brown

http://www.w3.org/2001/XMLSchema#string

Bruce R Ransom

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Christy Avery

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Chunling Chen

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Dorothy Jones

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Jyoti Dhar Malhotra

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Katie Kazarinova-Noyes

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Kristin A Kazen-Gillespie

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Patrick J Gillespie

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Peter Shrager

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P2860

Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.

Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses

Interaction of voltage-gated sodium channels with the extracellular matrix molecules tenascin-C and tenascin-R

Sodium channel beta1 and beta3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain

Sodium channel beta subunits mediate homophilic cell adhesion and recruit ankyrin to points of cell-cell contact

From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels

Contactin associates with Na+ channels and increases their functional expression

Structural requirements for interaction of sodium channel beta 1 subunits with ankyrin

Modification of seizure activity by electrical stimulation. II. Motor seizure

Structure and function of the beta 2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

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17072-17077

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10.1073/PNAS.212638099

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26

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99

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2002-12-12T00:00:00Z

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10991949

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12481039

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139271

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