Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice
about
Establishment of lal-/- myeloid lineage cell line that resembles myeloid-derived suppressive cellsPanax notoginseng saponins attenuate atherosclerosis in rats by regulating the blood lipid profile and an anti-inflammatory actionApi6/AIM/Spα/CD5L overexpression in alveolar type II epithelial cells induces spontaneous lung adenocarcinomaCritical roles of lysosomal acid lipase in myelopoiesis.Inhibition Role of Atherogenic Diet on Ethyl Carbamate Induced Lung Tumorigenesis in C57BL/6J Mice.Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions.Gene profile of myeloid-derived suppressive cells from the bone marrow of lysosomal acid lipase knock-out mice.Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient miceActivation of mTOR pathway in myeloid-derived suppressor cells stimulates cancer cell proliferation and metastasis in lal(-/-) miceOverexpression of dominant negative peroxisome proliferator-activated receptor-γ (PPARγ) in alveolar type II epithelial cells causes inflammation and T-cell suppression in the lung.Matrix metalloproteinase 12 overexpression in myeloid lineage cells plays a key role in modulating myelopoiesis, immune suppression, and lung tumorigenesis.Macrophage-specific expression of human lysosomal acid lipase corrects inflammation and pathogenic phenotypes in lal-/- mice.Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- miceInhibition of PPARγ in myeloid-lineage cells induces systemic inflammation, immunosuppression, and tumorigenesis.Activation of sterol-response element-binding proteins (SREBP) in alveolar type II cells enhances lipogenesis causing pulmonary lipotoxicity.PPARs in alveolar macrophage biology.Critical role of PPARγ in myeloid-derived suppressor cell-stimulated cancer cell proliferation and metastasis.Myeloid-specific expression of Api6/AIM/Sp alpha induces systemic inflammation and adenocarcinoma in the lungCritical roles of lysosomal acid lipase in T cell development and function.Matrix metalloproteinase 12 overexpression in lung epithelial cells plays a key role in emphysema to lung bronchioalveolar adenocarcinoma transition.Agonistic induction of PPARγ reverses cigarette smoke-induced emphysema.Lysosomal acid lipase in mesenchymal stem cell stimulation of tumor growth and metastasis.Epigenetic contributions to the developmental origins of adult lung disease.AIM/CD5L: a key protein in the control of immune homeostasis and inflammatory disease.Retinal pigment epithelium and microglia express the CD5 antigen-like protein, a novel autoantigen in age-related macular degeneration.Atherogenic high cholesterol/high fat diet induces TLRs-associated pulmonary inflammation in C57BL/6J mice.Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-/-) Mice.Association of Serum Lipids and Obstructive Lung Disease in Hispanic/Latino Adults of Diverse Backgrounds.Lung Epithelial Cell-Specific Expression of Human Lysosomal Acid Lipase Ameliorates Lung Inflammation and Tumor Metastasis in Lipa(-/-) MiceGene delivery by the hSP-B promoter to lung alveolar type II epithelial cells in LAL-knockout mice through bone marrow mesenchymal stem cells.Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung.Radiation-induced pulmonary gene expression changes are attenuated by the CTGF antibody Pamrevlumab.Myeloid-specific expression of Stat3C results in conversion of bone marrow mesenchymal stem cells into alveolar type II epithelial cells in the lung.
P2860
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P2860
Neutral lipids and peroxisome proliferator-activated receptor-{gamma} control pulmonary gene expression and inflammation-triggered pathogenesis in lysosomal acid lipase knockout mice
description
2005 nî lūn-bûn
@nan
2005 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@ast
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@en
type
label
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@ast
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@en
prefLabel
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@ast
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@en
P2093
P2860
P921
P1476
Neutral lipids and peroxisome ...... omal acid lipase knockout mice
@en
P2093
P2860
P304
P356
10.1016/S0002-9440(10)62053-6
P407
P577
2005-09-01T00:00:00Z