Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.
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A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexesIndividuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathyMutations in axonemal dynein assembly factor DNAAF3 cause primary ciliary dyskinesia.Nephrocystin-3 is required for ciliary function in zebrafish embryosCSAP localizes to polyglutamylated microtubules and promotes proper cilia function and zebrafish developmentThe coiled-coil domain containing protein CCDC40 is essential for motile cilia function and left-right axis formationDeletions and point mutations of LRRC50 cause primary ciliary dyskinesia due to dynein arm defectsLoss-of-function mutations in the human ortholog of Chlamydomonas reinhardtii ODA7 disrupt dynein arm assembly and cause primary ciliary dyskinesiaDirect and indirect roles for Nodal signaling in two axis conversions during asymmetric morphogenesis of the zebrafish heartCharacterization of tetratricopeptide repeat-containing proteins critical for cilia formation and functionIntraciliary calcium oscillations initiate vertebrate left-right asymmetryThe exocyst protein Sec10 interacts with Polycystin-2 and knockdown causes PKD-phenotypesAntennas of organ morphogenesis: the roles of cilia in vertebrate kidney developmentModelling a ciliopathy: Ahi1 knockdown in model systems reveals an essential role in brain, retinal, and renal developmentThe ciliary protein Nek8/Nphp9 acts downstream of Inv/Nphp2 during pronephros morphogenesis and left-right establishment in zebrafishThe coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animalsNovel roles for the radial spoke head protein 9 in neural and neurosensory cilia.Mutations in zebrafish leucine-rich repeat-containing six-like affect cilia motility and result in pronephric cysts, but have variable effects on left-right patterning.Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesisReptin/Ruvbl2 is a Lrrc6/Seahorse interactor essential for cilia motility.The dynein regulatory complex is required for ciliary motility and otolith biogenesis in the inner ear.Sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesisMutations in LRRC50 predispose zebrafish and humans to seminomas.Mutant polycystin-2 induces proliferation in primary rat tubular epithelial cells in a STAT-1/p21-independent fashion accompanied instead by alterations in expression of p57KIP2 and Cdk2.Lights on for aminopeptidases in cystic kidney disease.Cytoplasmic carboxypeptidase 5 regulates tubulin glutamylation and zebrafish cilia formation and functionGenome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.The zebrafish orthologue of the dyslexia candidate gene DYX1C1 is essential for cilia growth and functionInhibition of the P2X7 receptor reduces cystogenesis in PKD.IFT46 plays an essential role in cilia developmentEuFishBioMed (COST Action BM0804): a European network to promote the use of small fishes in biomedical research.The centriolar satellite proteins Cep72 and Cep290 interact and are required for recruitment of BBS proteins to the cilium.Mechanism for generation of left isomerism in Ccdc40 mutant embryos.Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning.c21orf59/kurly Controls Both Cilia Motility and PolarizationDevelopmental localization of nephrin in zebrafish and medaka pronephric glomerulus.Cdc42 deficiency causes ciliary abnormalities and cystic kidneys.Finfish and aquatic invertebrate pathology resources for now and the future.Calcium signaling: a common thread in vertebrate left-right axis development.Zebrafish kidney development: basic science to translational research.
P2860
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P2860
Zebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.
description
2007 nî lūn-bûn
@nan
2007 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
name
Zebrafish mutations affecting ...... t differs from pkd2 morphants.
@ast
Zebrafish mutations affecting ...... t differs from pkd2 morphants.
@en
type
label
Zebrafish mutations affecting ...... t differs from pkd2 morphants.
@ast
Zebrafish mutations affecting ...... t differs from pkd2 morphants.
@en
prefLabel
Zebrafish mutations affecting ...... t differs from pkd2 morphants.
@ast
Zebrafish mutations affecting ...... t differs from pkd2 morphants.
@en
P2093
P2860
P1476
Zebrafish mutations affecting ...... at differs from pkd2 morphants
@en
P2093
Christine L Hostetter
Fabrizio C Serluca
Jessica Sullivan-Brown
Jodi Schottenfeld
Noriko Okabe
P2860
P304
P356
10.1016/J.YDBIO.2007.11.025
P407
P577
2007-12-03T00:00:00Z