Cardiac defects and renal failure in mice with targeted mutations in Pkd2
about
Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascadesInternational Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyThe RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activityVascular complications in autosomal dominant polycystic kidney diseaseA polycystin-centric view of cyst formation and disease: the polycystins revisitedPodocyte pathology and nephropathy - sphingolipids in glomerular diseasesPkd1 and Pkd2 are required for normal placental developmentIdentification of MMP1 as a novel risk factor for intracranial aneurysms in ADPKD using iPSC models.Antennas of organ morphogenesis: the roles of cilia in vertebrate kidney developmentIn vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determinationMutations of the human polycystic kidney disease 2 (PKD2) geneRegulation of calcium signaling by polycystin-2Bilineal disease and trans-heterozygotes in autosomal dominant polycystic kidney disease.Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 geneRegulation of ryanodine receptor-dependent calcium signaling by polycystin-2Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesisLoss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptorsPolycystin 1 is required for the structural integrity of blood vesselsPkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cystsOsteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposityPkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cellsA genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formationFibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and functionZebrafish mutations affecting cilia motility share similar cystic phenotypes and suggest a mechanism of cyst formation that differs from pkd2 morphants.Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathyPolycystin signaling is required for directed endothelial cell migration and lymphatic developmentSitus inversus and ciliary abnormalities: 20 years later, what is the connection?PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice.Hypertension in autosomal dominant polycystic kidney disease.Evidence of extraordinary growth in the progressive enlargement of renal cysts.Murine Models of Polycystic Kidney Disease.Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Replacement of Rbpj with Rbpjl in the PTF1 complex controls the final maturation of pancreatic acinar cells.Polycystic kidney disease: In danger of being X-rated?Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.Drosophila Pkd2 is haploid-insufficient for mediating optimal smooth muscle contractility.Distinct patterns of kidney and liver cyst growth in pkd2(WS25/-) miceMetabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury.
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P2860
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
description
2000 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հունվարին հրատարակված գիտական հոդված
@hy
articolo scientifico
@it
artikull shkencor
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artículu científicu espublizáu en 2000
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im Januar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
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wetenschappelijk artikel
@nl
наукова стаття, опублікована в січні 2000
@uk
مقالة علمية (نشرت عام 2000)
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name
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@ast
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@en
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@nl
type
label
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@ast
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@en
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@nl
prefLabel
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@ast
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@en
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@nl
P2093
P2860
P3181
P356
P1433
P1476
Cardiac defects and renal failure in mice with targeted mutations in Pkd2
@en
P2093
G. S. Markowitz
J. H. Park
J. Tuchman
J. van Adelsberg
R. Kucherlapati
S. M. Factor
P2860
P2888
P3181
P356
10.1038/71724
P407
P577
2000-01-01T00:00:00Z