Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.
about
Three decades of beta-lactamase inhibitorsSulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamaseCrystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamaseThe Importance of thetrans-Enamine Intermediate as a β-Lactamase Inhibition Strategy Probed in Inhibitor-Resistant SHV β-Lactamase Variantsβ-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-EnzymeStructure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric RegulationCrystal Structure of the Extended-Spectrum -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with -Lactams and -Lactamase InhibitorsTargeting Antibiotic ResistanceKinetic crystallography by Raman microscopy.Why the extended-spectrum beta-lactamases SHV-2 and SHV-5 are "hypersusceptible" to mechanism-based inhibitorsInhibition of OXA-1 beta-lactamase by penems.Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidenceThe role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.Synergy within structural biology of single crystal optical spectroscopy and X-ray crystallography.Identification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.Avibactam and inhibitor-resistant SHV β-lactamasesExposing a β-Lactamase "Twist": the Mechanistic Basis for the High Level of Ceftazidime Resistance in the C69F Variant of the Burkholderia pseudomallei PenI β-Lactamase.Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030New techniques in antibiotic discovery and resistance: Raman spectroscopy.N152G, -S, and -T substitutions in CMY-2 β-lactamase increase catalytic efficiency for cefoxitin and inactivation rates for tazobactam.Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme.Carbapenems and SHV-1 beta-lactamase form different acyl-enzyme populations in crystals and solution.Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.
P2860
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P2860
Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.
description
2006 nî lūn-bûn
@nan
2006 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@ast
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@en
type
label
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@ast
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@en
prefLabel
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@ast
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@en
P2093
P2860
P356
P1433
P1476
Effect of the inhibitor-resist ...... beta-lactamase intermediates.
@en
P2093
Focco van den Akker
Marianne P Carey
Marion S Helfand
Monica A Totir
Paul R Carey
Pius S Padayatti
P2860
P304
11895-11904
P356
10.1021/BI060990M
P407
P577
2006-10-01T00:00:00Z