Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure
about
Three decades of beta-lactamase inhibitorsSulbactam forms only minimal amounts of irreversible acrylate-enzyme with SHV-1 beta-lactamaseLigand-Dependent Disorder of the Loop Observed in Extended-Spectrum SHV-Type -LactamaseCrystal Structure of a Preacylation Complex of the β-Lactamase Inhibitor Sulbactam Bound to a Sulfenamide Bond-Containing Thiol-β-lactamaseβ-Lactamase Inhibition by 7-Alkylidenecephalosporin Sulfones: Allylic Transposition and Formation of an Unprecedented Stabilized Acyl-EnzymePenam Sulfones and β-Lactamase Inhibition: SA2-13 and the Importance of the C2 Side Chain Length and CompositionCrystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibioticsKinetic crystallography by Raman microscopy.Effect of the inhibitor-resistant M69V substitution on the structures and populations of trans-enamine beta-lactamase intermediates.Why the extended-spectrum beta-lactamases SHV-2 and SHV-5 are "hypersusceptible" to mechanism-based inhibitorsDetecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfoneClavulanic acid inactivation of SHV-1 and the inhibitor-resistant S130G SHV-1 beta-lactamase. Insights into the mechanism of inhibition.Different intermediate populations formed by tazobactam, sulbactam, and clavulanate reacting with SHV-1 beta-lactamases: Raman crystallographic evidenceIdentification of products of inhibition of GES-2 beta-lactamase by tazobactam by x-ray crystallography and spectrometry.Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study.Crystal Structures of KPC-2 and SHV-1 β-Lactamases in Complex with the Boronic Acid Transition State Analog S02030Mutation of the active site carboxy-lysine (K70) of OXA-1 beta-lactamase results in a deacylation-deficient enzyme.Following DNA chain extension and protein conformational changes in crystals of a Y-family DNA polymerase via Raman crystallography.New techniques in antibiotic discovery and resistance: Raman spectroscopy.The road to avibactam: the first clinically useful non-β-lactam working somewhat like a β-lactam.Raman spectra of interchanging β-lactamase inhibitor intermediates on the millisecond time scale.Rational design of a beta-lactamase inhibitor achieved via stabilization of the trans-enamine intermediate: 1.28 A crystal structure of wt SHV-1 complex with a penam sulfoneMolecular dynamics and molecular docking studies on E166A point mutant, R274N/R276N double mutant, and E166A/R274N/R276N triple mutant forms of class A β-lactamases.High resolution crystal structures of the trans-enamine intermediates formed by sulbactam and clavulanic acid and E166A SHV-1 {beta}-lactamase.Mechanisms of proton relay and product release by Class A β-lactamase at ultrahigh resolution.Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches.
P2860
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P2860
Tazobactam forms a stoichiometric trans-enamine intermediate in the E166A variant of SHV-1 beta-lactamase: 1.63 A crystal structure
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2004 nî lūn-bûn
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2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
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2004 թվականի փետրվարին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@ast
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@en
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
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label
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@ast
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@en
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@nl
prefLabel
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@ast
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@en
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@nl
P2093
P50
P356
P1433
P1476
Tazobactam forms a stoichiomet ...... mase: 1.63 A crystal structure
@en
P2093
Marianne P Carey
Marion S Helfand
Monica A Totir
Paul R Carey
Pius S Padayatti
P356
10.1021/BI035985M
P407
P577
2004-02-03T00:00:00Z