Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus. - Wikidata - awgldk - TriplyDB

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.

http://www.wikidata.org/entity/Q30493784

about

Triclocarban mediates induction of xenobiotic metabolism through activation of the constitutive androstane receptor and the estrogen receptor alpha A novel newborn rat kernicterus model created by injecting a bilirubin solution into the cisterna magna Structure and Protein-Protein Interactions of Human UDP-Glucuronosyltransferases Drug-Metabolizing Activity, Protein and Gene Expression of UDP-Glucuronosyltransferases Are Significantly Altered in Hepatocellular Carcinoma Patients Rescue of bilirubin-induced neonatal lethality in a mouse model of Crigler-Najjar syndrome type I by AAV9-mediated gene transfer Glucuronidation of drugs and drug-induced toxicity in humanized UDP-glucuronosyltransferase 1 mice.Bilirubin uridine diphosphate-glucuronosyltransferase variation is a genetic basis of breast milk jaundice.Pharmacogenomics of drug-metabolizing enzymes: a recent update on clinical implications and endogenous effects.Importance of UDP-glucuronosyltransferase 1A1 expression in skin and its induction by UVB in neonatal hyperbilirubinemia The UDP-glucuronosyltransferases of the blood-brain barrier: their role in drug metabolism and detoxication.Drug-metabolizing enzyme, transporter, and nuclear receptor genetically modified mouse models.Inhibition of human UGT2B7 gene expression in transgenic mice by the constitutive androstane receptor.Multiple Genetic Modifiers of Bilirubin Metabolism Involvement in Significant Neonatal Hyperbilirubinemia in Patients of Chinese Descent Expression of UDP-Glucuronosyltransferase 1 (UGT1) and Glucuronidation Activity toward Endogenous Substances in Humanized UGT1 Mouse Brain Expression of Human DNAJ (Heat Shock Protein-40) B3 in Humanized UDP-glucuronosyltransferase 1 Mice The evolving landscape of neurotoxicity by unconjugated bilirubin: role of glial cells and inflammation.Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice.Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-κB leads to hyperbilirubinemia.Reduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal Hyperbilirubinemia Role of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.Nicotine regulates the expression of UDP-glucuronosyltransferase (UGT) in humanized UGT1 mouse brain.Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase1 mice.Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model.Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications.Transcriptional regulation of human UDP-glucuronosyltransferase genes.Glucose induces intestinal human UDP-glucuronosyltransferase (UGT) 1A1 to prevent neonatal hyperbilirubinemia.Prediction of drug-induced liver injury using keratinocytes Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia.Inhibitory effect of 5β-pregnane-3α,20β-diol on transcriptional activity and enzyme activity of human bilirubin UDP-glucuronosyltransferase.Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia.Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity.Glucuronidation of drugs in humanized UDP-glucuronosyltransferase 1 mice: Similarity with glucuronidation in human liver microsomes.Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.Isothiocyanates induce UGT1A1 in humanized UGT1 mice in a CAR dependent fashion that is highly dependent upon oxidative stress.Impact of fatty acids on human UDP-glucuronosyltransferase 1A1 activity and its expression in neonatal hyperbilirubinemia.Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα.Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans.Acyl-glucuronide as a Possible Cause of Trovafloxacin-Induced Liver Toxicity: Induction of Chemokine (C-X-C Motif) Ligand 2 by Trovafloxacin Acyl-glucuronide.Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model

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P2860

Developmental hyperbilirubinemia and CNS toxicity in mice humanized with the UDP glucuronosyltransferase 1 (UGT1) locus.

http://www.wikidata.org/entity/Q30493784

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

@zh-hk

2010年論文

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2010年論文

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2010年论文

@wuu

name

Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

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Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

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type

label

Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

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Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

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prefLabel

Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

@ast

Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

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PNAS.0913290107

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Developmental hyperbilirubinem ...... syltransferase 1 (UGT1) locus.

@en

P2093

Nghia Nguyen

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Robert H Tukey

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Ryoichi Fujiwara

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Shujuan Chen

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P2860

Biliverdin reductase: a major physiologic cytoprotectant

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome

Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man

Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle

Nrf2-Keap1 signaling pathway regulates human UGT1A1 expression in vitro and in transgenic UGT1 mice

Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene

Bilirubin toxicity in the developing nervous system.

Definition of the clinical spectrum of kernicterus and bilirubin-induced neurologic dysfunction (BIND).

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5024-5029

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10.1073/PNAS.0913290107

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11

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107

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41656837

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20194756

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bilirubin metabolic disorder

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2841904

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