Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).
about
Structure and Protein-Protein Interactions of Human UDP-GlucuronosyltransferasesOld drug new use--amoxapine and its metabolites as potent bacterial β-glucuronidase inhibitors for alleviating cancer drug toxicity.Structure and Inhibition of Microbiome β-Glucuronidases Essential to the Alleviation of Cancer Drug ToxicityReduced Myelination and Increased Glia Reactivity Resulting from Severe Neonatal HyperbilirubinemiaRole of extrahepatic UDP-glucuronosyltransferase 1A1: Advances in understanding breast milk-induced neonatal hyperbilirubinemia.Irinotecan (CPT-11)-induced elevation of bile acids potentiates suppression of IL-10 expression.Reduction of p53 by knockdown of the UGT1 locus in colon epithelial cells causes an increase in tumorigenesis.Development of nanoliposomal irinotecan (nal-IRI, MM-398, PEP02) in the management of metastatic pancreatic cancer.Pharmacogenetics of irinotecan, doxorubicin and docetaxel transporters in Asian and Caucasian cancer patients: a comparative review.Irinotecan- and 5-fluorouracil-induced intestinal mucositis: insights into pathogenesis and therapeutic perspectives.Developmental, Genetic, Dietary, and Xenobiotic Influences on Neonatal Hyperbilirubinemia.Cadmium and arsenic override NF-κB developmental regulation of the intestinal UGT1A1 gene and control of hyperbilirubinemia.Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.Species differences in drug glucuronidation: Humanized UDP-glucuronosyltransferase 1 mice and their application for predicting drug glucuronidation and drug-induced toxicity in humans.Systems Pharmacology Model of Gastrointestinal Damage Predicts Species Differences and Optimizes Clinical Dosing Schedules.Crypt Organoid Culture as an in Vitro Model in Drug Metabolism and Cytotoxicity Studies.Herb-drug interaction between irinotecan and psoralidin-containing herbs.Chiral Inhibition of Rivaroxaban Derivatives Towards UDP-Glucuronosyltransferase (UGT) Isoforms.A novel genetic score model of UGT1A1 and TGFB pathway as predictor of severe irinotecan-related diarrhea in metastatic colorectal cancer patients.Two birds, one stone: hesperetin alleviates chemotherapy-induced diarrhea and potentiates tumor inhibition.
P2860
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P2860
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11).
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Intestinal glucuronidation pro ...... xicity by irinotecan (CPT-11).
@en
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan
@nl
type
label
Intestinal glucuronidation pro ...... xicity by irinotecan (CPT-11).
@en
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan
@nl
prefLabel
Intestinal glucuronidation pro ...... xicity by irinotecan (CPT-11).
@en
Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan
@nl
P2093
P2860
P356
P1476
Intestinal glucuronidation pro ...... xicity by irinotecan (CPT-11).
@en
P2093
Cyril Bigo
Kepeng Wang
Mei-Fei Yueh
Nghia Nguyen
Olivier Barbier
Robert H Tukey
Shujuan Chen
P2860
P304
19143-19148
P356
10.1073/PNAS.1319123110
P407
P577
2013-11-04T00:00:00Z