Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.
about
The Growing Complexity of Cancer Cell Response to DNA-Damaging Agents: Caspase 3 Mediates Cell Death or Survival?Aurora kinase inhibition induces PUMA via NF-κB to kill colon cancer cells.Design of libraries targeting protein-protein interfaces.Dynamin inhibitors induce caspase-mediated apoptosis following cytokinesis failure in human cancer cells and this is blocked by Bcl-2 overexpression.Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cellsThe Novel ATP-Competitive MEK/Aurora Kinase Inhibitor BI-847325 Overcomes Acquired BRAF Inhibitor Resistance through Suppression of Mcl-1 and MEK ExpressionInhibition of Bcl-xL overcomes polyploidy resistance and leads to apoptotic cell death in acute myeloid leukemia cells.Resistance to HSP90 inhibition involving loss of MCL1 addiction.Targeting aneuploid cancer cells.Significance of Wild-Type p53 Signaling in Suppressing Apoptosis in Response to Chemical Genotoxic Agents: Impact on Chemotherapy Outcome.Development of a high-content screening assay panel to accelerate mechanism of action studies for oncology research.Role of STAT3/5 and Bcl-2/xL in 2-methoxyestradiol-induced endoreduplication of nasopharyngeal carcinoma cells.Selective BCL-XL inhibition promotes apoptosis in combination with MLN8237 in medulloblastoma and pediatric glioblastoma cells.Phytochemical Inhibition of Multidrug Resistance Protein-1 as a Therapeutic Strategy for Hemangioendothelioma.Perturbing mitosis for anti-cancer therapy: is cell death the only answer?A novel therapeutic combination sequentially targeting aurora B and Bcl-xL in hepatocellular carcinoma.
P2860
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P2860
Bcl-XL represents a druggable molecular vulnerability during aurora B inhibitor-mediated polyploidization.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@ast
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@en
type
label
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@ast
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@en
prefLabel
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@ast
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@en
P2093
P2860
P356
P1476
Bcl-XL represents a druggable ...... tor-mediated polyploidization.
@en
P2093
Cherrie K Donawho
Joann Palma
Junling Li
Keith B Glaser
Leiming Li
Luis E Rodriguez
Mark G Anderson
O Jameel Shah
P2860
P304
12634-12639
P356
10.1073/PNAS.0913615107
P407
P577
2010-06-28T00:00:00Z