Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection
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Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signalingStructural and dynamic determinants of type I interferon receptor assembly and their functional interpretation.Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potencyThe Mon1-Ccz1 GEF activates the Rab7 GTPase Ypt7 via a longin-fold-Rab interface and association with PI3P-positive membranes.High efficiency cell-specific targeting of cytokine activityLive cell micropatterning reveals the dynamics of signaling complexes at the plasma membraneReceptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling.Fundamental aspects of protein-protein association kineticsA versatile toolbox for multiplexed protein micropatterning by laser lithography.Determination of the two-dimensional interaction rate constants of a cytokine receptor complex.kT-Scale interactions between supported lipid bilayers.In vitro test system for evaluation of immune activation potential of new single-stranded DNA-based therapeutics.Understanding cytokine and growth factor receptor activation mechanisms.Alteration of interferon-α/β receptors in chronic hepatitis B patientsLigand-independent interaction of the type I interferon receptor complex is necessary to observe its biological activity.Interferon beta induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation.Multivalent chelators for spatially and temporally controlled protein functionalization.Inquiring into the differential action of interferons (IFNs): an IFN-alpha2 mutant with enhanced affinity to IFNAR1 is functionally similar to IFN-beta.Structure of lipid multilayers via drop casting of aqueous liposome dispersions.NMR mapping of the IFNAR1-EC binding site on IFNalpha2 reveals allosteric changes in the IFNAR2-EC binding site.IFN-beta inhibits dendritic cell migration through STAT-1-mediated transcriptional suppression of CCR7 and matrix metalloproteinase 9.Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab.Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.The EM structure of a type I interferon-receptor complex reveals a novel mechanism for cytokine signaling.High-fidelity protein targeting into membrane lipid microdomains in living cells.Immunomodulatory and antitumor effects of type I interferons and their application in cancer therapy.Diffusion and interaction dynamics of individual membrane protein complexes confined in micropatterned polymer-supported membranes.Mathematical modelling and computational study of two-dimensional and three-dimensional dynamics of receptor-ligand interactions in signalling response mechanisms.Longitudinal system-based analysis of transcriptional responses to type I interferons.Engineered Ferritin for Magnetogenetic Manipulation of Proteins and Organelles Inside Living Cells.IFN alpha/beta binds to IFNAR2The stability of the ternary interferon-receptor complex rather than the affinity to the individual subunits dictates differential biological activities.Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials.Cytosolic GAPDH as a redox-dependent regulator of energy metabolism
P2860
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P2860
Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection
description
2005 nî lūn-bûn
@nan
2005 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի մարտին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Lateral ligand-receptor intera ...... escence-interference detection
@ast
Lateral ligand-receptor intera ...... escence-interference detection
@en
type
label
Lateral ligand-receptor intera ...... escence-interference detection
@ast
Lateral ligand-receptor intera ...... escence-interference detection
@en
prefLabel
Lateral ligand-receptor intera ...... escence-interference detection
@ast
Lateral ligand-receptor intera ...... escence-interference detection
@en
P2093
P2860
P1433
P1476
Lateral ligand-receptor intera ...... escence-interference detection
@en
P2093
Jacob Piehler
Martynas Gavutis
Peter Lamken
Pia Müller
Suman Lata
P2860
P304
P356
10.1529/BIOPHYSJ.104.055855
P407
P577
2005-03-18T00:00:00Z