A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
about
Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2Molding BRCA2 function through its interacting partnersPALB2: the hub of a network of tumor suppressors involved in DNA damage responsesCTCF facilitates DNA double-strand break repair by enhancing homologous recombination repair.Cancer suppression by the chromosome custodians, BRCA1 and BRCA2.Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.Functional genomics screening utilizing mutant mouse embryonic stem cells identifies novel radiation-response genes.BRPF3-HBO1 regulates replication origin activation and histone H3K14 acetylationHomologous recombination and its regulationBRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response.BRCA1 downregulates the kinase activity of Polo-like kinase 1 in response to replication stressHeterozygous mutations in PALB2 cause DNA replication and damage response defects.BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.Analysis of chromosomal radiosensitivity of healthy BRCA2 mutation carriers and non-carriers in BRCA families with the G2 micronucleus assayCheckpoint control and cancer.Chromosome instability and carcinogenesis: insights from murine models of human pancreatic cancer associated with BRCA2 inactivationPathways for genome integrity in G2 phase of the cell cycle.ATM/ATR-mediated phosphorylation of PALB2 promotes RAD51 function.Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.DNA damage response and hematological malignancy.Hypoxia-induced alterations of G2 checkpoint regulators.BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage.Full in-frame exon 3 skipping of BRCA2 confers high risk of breast and/or ovarian cancer.Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer
P2860
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P2860
A genetic screen identifies BRCA2 and PALB2 as key regulators of G2 checkpoint maintenance
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2011 nî lūn-bûn
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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
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2011 թվականի հուլիսին հրատարակված գիտական հոդված
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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A genetic screen identifies BR ...... s of G2 checkpoint maintenance
@ast
A genetic screen identifies BR ...... s of G2 checkpoint maintenance
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type
label
A genetic screen identifies BR ...... s of G2 checkpoint maintenance
@ast
A genetic screen identifies BR ...... s of G2 checkpoint maintenance
@en
prefLabel
A genetic screen identifies BR ...... s of G2 checkpoint maintenance
@ast
A genetic screen identifies BR ...... s of G2 checkpoint maintenance
@en
P2093
P2860
P356
P1433
P1476
A genetic screen identifies BR ...... s of G2 checkpoint maintenance
@en
P2093
Christin Lund-Andersen
Ditte Kjærsgaard Klein
Jens Vilstrup Johansen
Michael Lees
Randi G Syljuåsen
Tobias Menzel
Viola Nähse-Kumpf
P2860
P304
P356
10.1038/EMBOR.2011.99
P577
2011-07-01T00:00:00Z