Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression - Wikidata - awgldk - TriplyDB

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

http://www.wikidata.org/entity/Q30503281

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Bacterial Toxins as Pathogen Weapons Against Phagocytes MicroRNA regulation of T-lymphocyte immunity: modulation of molecular networks responsible for T-cell activation, differentiation, and development microRNAs function in CD8+T cell biology The pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ER Kinetics of mycolactone in human subcutaneous tissue during antibiotic therapy for Mycobacterium ulcerans disease Quantification and accurate normalisation of small RNAs through new custom RT-qPCR arrays demonstrates Salmonella-induced microRNAs in human monocytes On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer.Structure-activity relationship studies on the macrolide exotoxin mycolactone of Mycobacterium ulcerans.Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells.Combined inflammatory and metabolic defects reflected by reduced serum protein levels in patients with Buruli ulcer disease Shaping mycolactone for therapeutic use against inflammatory disorders.Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice.Antibody-Mediated Neutralization of the Exotoxin Mycolactone, the Main Virulence Factor Produced by Mycobacterium ulcerans Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation.Mycolactone-mediated neurite degeneration and functional effects in cultured human and rat DRG neurons: Mechanisms underlying hypoalgesia in Buruli ulcer Mycolactone subverts immunity by selectively blocking the Sec61 translocon.History, biology and chemistry of Mycobacterium ulcerans infections (Buruli ulcer disease).Pathogenesis of skin ulcers: lessons from the Mycobacterium ulcerans and Leishmania spp. pathogens.Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.Recent advances: role of mycolactone in the pathogenesis and monitoring of Mycobacterium ulcerans infection/Buruli ulcer disease.Investigation of wild-type and mycolactone-negative mutant Mycobacterium ulcerans on skeletal muscle: IGF-1 protects against mycolactone-induced muscle catabolism.Infiltrating leukocytes surround early Buruli ulcer lesions, but are unable to reach the mycolactone producing mycobacteria.The chemistry and biology of mycolactones.Soluble HLA-G modulates miRNA-210 and miRNA-451 expression in activated CD4+ T lymphocytes.Mycolactone displays anti-inflammatory effects on the nervous system.Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.The potent effect of mycolactone on lipid membranes.Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and Distinctive Stress Signature IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with infection

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Mycolactone impairs T cell homing by suppressing microRNA control of L-selectin expression

http://www.wikidata.org/entity/Q30503281

description

2011 nî lūn-bûn

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2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հուլիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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type

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Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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PNAS.1016496108

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Proceedings of the National Academy of Sciences of the United States of America

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Mycolactone impairs T cell hom ...... ntrol of L-selectin expression

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Agnès Le Bon

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Caroline Demangel

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Florent Carrette

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François Asperti-Boursin

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Georges Bismuth

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Laure Guenin-Macé

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Laxmee Caleechurn

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Vincenzo Di Bartolo

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P2860

Mycolactone diffuses from Mycobacterium ulcerans-infected tissues and targets mononuclear cells in peripheral blood and lymphoid organs

MicroRNA-373 induces expression of genes with complementary promoter sequences

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

Widespread changes in protein synthesis induced by microRNAs

Kruppel-like factor 2 regulates thymocyte and T-cell migration

let-7 microRNAs in development, stem cells and cancer

Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor.

Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse

CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3-kinase-independent manner.

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31

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108

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Arnaud Fontanet

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2011-07-18T00:00:00Z

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51501468

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21768364

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3150933

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