Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.
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Bacterial Toxins as Pathogen Weapons Against PhagocytesThe pathogenic mechanism of the Mycobacterium ulcerans virulence factor, mycolactone, depends on blockade of protein translocation into the ERLocally Confined Clonal Complexes of Mycobacterium ulcerans in Two Buruli Ulcer Endemic Regions of CameroonMacrophage cytokines: involvement in immunity and infectious diseasesShaping mycolactone for therapeutic use against inflammatory disorders.Recombinant BCG Expressing Mycobacterium ulcerans Ag85A Imparts Enhanced Protection against Experimental Buruli ulcer.Interferon-γ Is a Crucial Activator of Early Host Immune Defense against Mycobacterium ulcerans Infection in Mice.Metabolomic profiles delineate mycolactone signature in Buruli ulcer disease.The untapped cell biology of neglected tropical diseases.Mycolactone subverts immunity by selectively blocking the Sec61 translocon.Revisiting Buruli ulcer.Mycolactone reveals the substrate-driven complexity of Sec61-dependent transmembrane protein biogenesis.Mycolactone displays anti-inflammatory effects on the nervous system.Membrane perturbing properties of toxin mycolactone from Mycobacterium ulcerans.The potent effect of mycolactone on lipid membranes.Control and regulation of mRNA translation.Inhibition of Sec61-dependent translocation by mycolactone uncouples the integrated stress response from ER stress, driving cytotoxicity via translational activation of ATF4.Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulceransIFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with infection
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P2860
Pleiotropic molecular effects of the Mycobacterium ulcerans virulence factor mycolactone underlying the cell death and immunosuppression seen in Buruli ulcer.
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article científic
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article scientifique
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articol științific
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articolo scientifico
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artigo científico
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artigo científico
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artigo científico
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artikel ilmiah
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artikull shkencor
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artículo científico
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Pleiotropic molecular effects ...... pression seen in Buruli ulcer.
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type
label
Pleiotropic molecular effects ...... pression seen in Buruli ulcer.
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prefLabel
Pleiotropic molecular effects ...... pression seen in Buruli ulcer.
@en
P2860
P356
P1476
Pleiotropic molecular effects ...... pression seen in Buruli ulcer.
@en
P2093
Belinda Hall
Rachel Simmonds
P2860
P304
P356
10.1042/BST20130133
P577
2014-02-01T00:00:00Z