SMN is required for sensory-motor circuit function in Drosophila. - Wikidata - awgldk - TriplyDB

SMN is required for sensory-motor circuit function in Drosophila.

SMN is required for sensory-motor circuit function in Drosophila.

http://www.wikidata.org/entity/Q30525692

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Is spinal muscular atrophy a disease of the motor neurons only: pathogenesis and therapeutic implications?Spinal muscular atrophy: development and implementation of potential treatments Small molecule suppressors of Drosophila kinesin deficiency rescue motor axon development in a zebrafish model of spinal muscular atrophy Neuron-specific knock-down of SMN1 causes neuron degeneration and death through an apoptotic mechanism Small nuclear RNAs and mRNAs: linking RNA processing and transport to spinal muscular atrophy.Mutant human FUS Is ubiquitously mislocalized and generates persistent stress granules in primary cultured transgenic zebrafish cells Neural Circuits Underlying Fly Larval Locomotion Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy Shared mechanisms between Drosophila peripheral nervous system development and human neurodegenerative diseases GEMINs: potential therapeutic targets for spinal muscular atrophy?Identification of motor neurons and a mechanosensitive sensory neuron in the defecation circuitry of Drosophila larvae.Improvement of SMN2 pre-mRNA processing mediated by exon-specific U1 small nuclear RNA.Spinal muscular atrophy: diagnosis and management in a new therapeutic era A cell system for phenotypic screening of modifiers of SMN2 gene expression and function.Spinal muscular atrophy: from tissue specificity to therapeutic strategies SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.The Gemin associates of survival motor neuron are required for motor function in Drosophila.A stem-cell based bioassay to critically assess the pathology of dysfunctional neuromuscular junctions.The Genetics of Spinal Muscular Atrophy: Progress and Challenges.Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: evidence for involvement of splicing regulatory proteins.Genetic Interactions between the Members of the SMN-Gemins Complex in Drosophila.Connectivity and circuitry in a dish versus in a brain Disease mechanisms and therapeutic approaches in spinal muscular atrophy.An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy Genetic inhibition of JNK3 ameliorates spinal muscular atrophy.Behavioral and electrophysiological outcomes of tissue-specific Smn knockdown in Drosophila melanogaster.The pathogenicity of splicing defects: mechanistic insights into pre-mRNA processing inform novel therapeutic approaches.The DcpS inhibitor RG3039 improves motor function in SMA mice.Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes.SMN is essential for the biogenesis of U7 small nuclear ribonucleoprotein and 3'-end formation of histone mRNAs.Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease.Spinal muscular atrophy astrocytes exhibit abnormal calcium regulation and reduced growth factor production Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration.Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy.Spinal muscular atrophy: new findings for an old pathology.Spinal muscular atrophy: a motor neuron disorder or a multi-organ disease?Mechanisms for axon maintenance and plasticity in motoneurons: alterations in motoneuron disease.Minor splicing pathway is not minor any more: implications for the pathogenesis of motor neuron diseases.Gem depletion: amyotrophic lateral sclerosis and spinal muscular atrophy crossover.SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.

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P2860

SMN is required for sensory-motor circuit function in Drosophila.

http://www.wikidata.org/entity/Q30525692

description

2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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name

SMN is required for sensory-motor circuit function in Drosophila.

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SMN is required for sensory-motor circuit function in Drosophila.

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type

label

SMN is required for sensory-motor circuit function in Drosophila.

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SMN is required for sensory-motor circuit function in Drosophila.

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prefLabel

SMN is required for sensory-motor circuit function in Drosophila.

@ast

SMN is required for sensory-motor circuit function in Drosophila.

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J.CELL.2012.09.011

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SMN is required for sensory-motor circuit function in Drosophila.

@en

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Ben Jiwon Choi

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Erin S Beck

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Francesco Lotti

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P2860

Modeling spinal muscular atrophy in Drosophila

Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

Synaptic defects in the spinal and neuromuscular circuitry in a mouse model of spinal muscular atrophy

Positional cues in the Drosophila nerve cord: semaphorins pattern the dorso-ventral axis

Identification and characterization of a spinal muscular atrophy-determining gene

A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy

Peripheral multidendritic sensory neurons are necessary for rhythmic locomotion behavior in Drosophila larvae.

A sensory feedback circuit coordinates muscle activity in Drosophila.

CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

The role of the TRP channel NompC in Drosophila larval and adult locomotion

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427-439

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10.1016/J.CELL.2012.09.011

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2

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151

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Wendy L. Imlach

Livio Pellizzoni

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2012-10-01T00:00:00Z

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23063130

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