SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy. - Wikidata - awgldk - TriplyDB

SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.

SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.

http://www.wikidata.org/entity/Q35039158

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Single-Cell mRNA Profiling Reveals Cell-Type-Specific Expression of Neurexin Isoforms Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy.Spinal Muscular Atrophy: From Defective Chaperoning of snRNP Assembly to Neuromuscular Dysfunction.The Survival of Motor Neuron Protein Acts as a Molecular Chaperone for mRNP Assembly Quality control of assembly-defective U1 snRNAs by decapping and 5'-to-3' exonucleolytic digestion.Assays for the identification and prioritization of drug candidates for spinal muscular atrophy Transcriptome profiling of spinal muscular atrophy motor neurons derived from mouse embryonic stem cells Spinal muscular atrophy: journeying from bench to bedside The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish.Disease mechanisms and therapeutic approaches in spinal muscular atrophy.An Integrative Transcriptomic Analysis for Identifying Novel Target Genes Corresponding to Severity Spectrum in Spinal Muscular Atrophy The survival motor neuron gene smn-1 interacts with the U2AF large subunit gene uaf-1 to regulate Caenorhabditis elegans lifespan and motor functions.Genetic inhibition of JNK3 ameliorates spinal muscular atrophy.α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth Transcriptional enhancement of Smn levels in motoneurons is crucial for proper axon morphology in zebrafish.The Power of Human Protective Modifiers: PLS3 and CORO1C Unravel Impaired Endocytosis in Spinal Muscular Atrophy and Rescue SMA Phenotype RNA-sequencing of a mouse-model of spinal muscular atrophy reveals tissue-wide changes in splicing of U12-dependent introns.SMN control of RNP assembly: from post-transcriptional gene regulation to motor neuron disease.Fishing for causes and cures of motor neuron disorders.Invited review: decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art.Developing therapies for spinal muscular atrophy.Advances in understanding the role of disease-associated proteins in spinal muscular atrophy.Neurocalcin Delta Suppression Protects against Spinal Muscular Atrophy in Humans and across Species by Restoring Impaired Endocytosis.A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.Differential roles of α-, β-, and γ-actin in axon growth and collateral branch formation in motoneurons.Effects of cadmium, manganese, and lead on locomotor activity and neurexin 2a expression in zebrafish.Developmental regulation of SMN expression: pathophysiological implications and perspectives for therapy development in spinal muscular atrophy.Dietary vitamin B6 modulates the gene expression of myokines, Nrf2-related factors, myogenin and HSP60 in the skeletal muscle of rats.Small-molecule flunarizine increases SMN protein in nuclear Cajal bodies and motor function in a mouse model of spinal muscular atrophy.mRNP assembly, axonal transport, and local translation in neurodegenerative diseases.Biology and clinical relevance of noncoding sno/scaRNAs.Zebrafish Models of Rare Hereditary Pediatric Diseases.Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery

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P2860

SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.

http://www.wikidata.org/entity/Q35039158

description

2013 nî lūn-bûn

@nan

2013 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

@zh-hk

2013年論文

@zh-mo

2013年論文

@zh-tw

2013年论文

@wuu

name

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

@ast

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

@en

type

label

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

@ast

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

@en

prefLabel

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

@ast

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

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P1433

Human Molecular Genetics

P1476

SMN deficiency alters Nrxn2 ex ...... ls of spinal muscular atrophy.

@en

P2093

Christoph Winkler

http://www.w3.org/2001/XMLSchema#string

Himanshu Vyas

http://www.w3.org/2001/XMLSchema#string

Marieke Giegerich

http://www.w3.org/2001/XMLSchema#string

Martin Graf

http://www.w3.org/2001/XMLSchema#string

Pearl S Cheong

http://www.w3.org/2001/XMLSchema#string

Preeti Yadav

http://www.w3.org/2001/XMLSchema#string

Serene G P Lee

http://www.w3.org/2001/XMLSchema#string

Sinnakaruppan Mathavan

http://www.w3.org/2001/XMLSchema#string

P2860

A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

An assembly chaperone collaborates with the SMN complex to generate spliceosomal SnRNPs

The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins

The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis

Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins

Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin

Gemin proteins are required for efficient assembly of Sm-class ribonucleoproteins.

SAM68 regulates neuronal activity-dependent alternative splicing of neurexin-1

Transcriptome analysis of zebrafish embryogenesis using microarrays

A stoichiometric complex of neurexins and dystroglycan in brain

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1754-1770

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scholarly article

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10.1093/HMG/DDT567

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7

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P478

23

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Michael Sendtner

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2013-11-11T00:00:00Z

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258446041

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24218366

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P921

spinal muscular atrophy