Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.
about
KATs in cancer: functions and therapiesP300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells.Down-regulation of STAT3 expression using vector-based RNA interference promotes apoptosis in Hepatocarcinoma cells.Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening.MiR-125a suppresses tumor growth, invasion and metastasis in cervical cancer by targeting STAT3.Hydrogen Sulfide Attenuates Inflammatory Hepcidin by Reducing IL-6 Secretion and Promoting SIRT1-Mediated STAT3 Deacetylation.Activating JAK1 mutation may predict the sensitivity of JAK-STAT inhibition in hepatocellular carcinoma.STAT3 Undergoes Acetylation-dependent Mitochondrial Translocation to Regulate Pyruvate Metabolism.Simvastatin-induced cell cycle arrest through inhibition of STAT3/SKP2 axis and activation of AMPK to promote p27 and p21 accumulation in hepatocellular carcinoma cells.Targeting the histone orthography of cancer: drugs for writers, erasers and readers.STAT3 the oncogene - still eluding therapy?Hepatitis C Virus Exploits Death Receptor 6-mediated Signaling Pathway to Facilitate Viral Propagation.Ginkgolic Acid C 17:1, Derived from Ginkgo biloba Leaves, Suppresses Constitutive and Inducible STAT3 Activation through Induction of PTEN and SHP-1 Tyrosine Phosphatase.Garcinol sensitizes breast cancer cells to Taxol through the suppression of caspase-3/iPLA2 and NF-κB/Twist1 signaling pathways in a mouse 4T1 breast tumor model.Ginkgetin Blocks Constitutive STAT3 Activation and Induces Apoptosis through Induction of SHP-1 and PTEN Tyrosine Phosphatases.Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer.Targeting multiple oncogenic pathways for the treatment of hepatocellular carcinoma.Garcinol and Its Role in Chronic Diseases.Chalepin: A Compound from Ruta angustifolia L. Pers Exhibits Cell Cycle Arrest at S phase, Suppresses Nuclear Factor-Kappa B (NF-κB) Pathway, Signal Transducer and Activation of Transcription 3 (STAT3) Phosphorylation and Extrinsic Apoptotic PathwayMMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain.Disruption of STAT3-DNMT1 interaction by SH-I-14 induces re-expression of tumor suppressor genes and inhibits growth of triple-negative breast tumor.GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways.Safety profile of 40% Garcinol from Garcinia indica in experimental rodents.
P2860
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P2860
Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo.
description
2014 nî lūn-bûn
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2014 թուականի Մարտին հրատարակուած գիտական յօդուած
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2014 թվականի մարտին հրատարակված գիտական հոդված
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2014年の論文
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2014年論文
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2014年論文
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2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@ast
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@en
type
label
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@ast
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@en
prefLabel
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@ast
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@en
P2093
P2860
P50
P356
P1433
P1476
Inhibition of STAT3 dimerizati ...... arcinoma in vitro and in vivo.
@en
P2093
Alan Prem Kumar
Amit K Behera
Jeelan Basha
Kwong Fai Wong
Muthu K Shanmugam
Nagashayana Natesh
Snehajyoti Chatterjee
Tapas K Kundu
P2860
P2888
P356
10.1186/1476-4598-13-66
P577
2014-03-21T00:00:00Z
P5875
P6179
1022135144