Solvent accessibility of the thrombin-thrombomodulin interface.
about
Two different proteins that compete for binding to thrombin have opposite kinetic and thermodynamic profilesHydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeuticsAn unexpected twist in viral capsid maturationPredicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug DesignHydrogen Exchange Mass Spectrometry of Related Proteins with Divergent Sequences: A Comparative Study of HIV-1 Nef Allelic Variants.An examination of dynamics crosstalk between SH2 and SH3 domains by hydrogen/deuterium exchange and mass spectrometry.HK97 maturation studied by crystallography and H/2H exchange reveals the structural basis for exothermic particle transitions.Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.Epitope mapping of a monoclonal antibody against human thrombin by H/D-exchange mass spectrometry reveals selection of a diverse sequence in a highly conserved proteinBiophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution.Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study.Mass spectrometry-based approaches to protein-ligand interactions.Automated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments.Mass spectrometry of hydrogen/deuterium exchange in 70S ribosomal proteins from E. coli.Biophysical investigation of GpIbalpha binding to thrombin anion binding exosite II.NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.Critical salt bridges guide capsid assembly, stability, and maturation behavior in bacteriophage HK97Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.Fourier transform mass spectrometry to monitor hyaluronan-protein interactions: use of hydrogen/deuterium amide exchangeThe influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.Thrombomodulin Binding Selects the Catalytically Active Form of ThrombinPhosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination.Studies of biomolecular conformations and conformational dynamics by mass spectrometry.Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB.DNA interaction fold upon binding to NF-kappaBRapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS.Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases.Distinguishing direct binding interactions from allosteric effects in the protease-HK97 prohead I δ domain complex by amide H/D exchange mass spectrometry.Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS)Ligand binding to anion-binding exosites regulates conformational properties of thrombin.Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.Escherichia coli SufE sulfur transfer protein modulates the SufS cysteine desulfurase through allosteric conformational dynamics.Mass spectrometry based tools to investigate protein-ligand interactions for drug discovery.Hydrogen-exchange mass spectrometry for the study of intrinsic disorder in proteins.Thermodynamic compensation upon binding to exosite 1 and the active site of thrombinThe thrombin epitope recognizing thrombomodulin is a highly cooperative hot spot in exosite I.Amide H/2H exchange reveals a mechanism of thrombin activation.Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.Mutations in the fourth EGF-like domain affect thrombomodulin-induced changes in the active site of thrombin.Structure of melittin bound to phospholipid micelles studied using hydrogen-deuterium exchange and electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry.Application of amide proton exchange mass spectrometry for the study of protein-protein interactions.
P2860
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P2860
Solvent accessibility of the thrombin-thrombomodulin interface.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Solvent accessibility of the thrombin-thrombomodulin interface.
@ast
Solvent accessibility of the thrombin-thrombomodulin interface.
@en
type
label
Solvent accessibility of the thrombin-thrombomodulin interface.
@ast
Solvent accessibility of the thrombin-thrombomodulin interface.
@en
prefLabel
Solvent accessibility of the thrombin-thrombomodulin interface.
@ast
Solvent accessibility of the thrombin-thrombomodulin interface.
@en
P2093
P356
P1476
Solvent accessibility of the thrombin-thrombomodulin interface.
@en
P2093
A Baerga-Ortiz
E A Komives
J G Mandell
P304
P356
10.1006/JMBI.2000.4416
P407
P577
2001-02-01T00:00:00Z