about
The generality of DNA-templated synthesis as a basis for evolving non-natural small moleculesRecombining low homology, functionally rich regions of bacterial subtilisins by combinatorial fragment exchangeVery long-term memories may be stored in the pattern of holes in the perineuronal net.DNA shuffling method for generating highly recombined genes and evolved enzymes.Phage-display evolution of tyrosine kinases with altered nucleotide specificity.Functional expression of horseradish peroxidase in Saccharomyces cerevisiae and Pichia pastoris.Library analysis of SCHEMA-guided protein recombination.Transmutation of human glutathione transferase A2-2 with peroxidase activity into an efficient steroid isomerase.Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization.Directed evolution of a glycosynthase from Agrobacterium sp. increases its catalytic activity dramatically and expands its substrate repertoire.Laboratory-directed protein evolutionDevelopment of innovative pediocin PA-1 by DNA shuffling among class IIa bacteriocinsDirected evolution of a recombinase for improved genomic integration at a native human sequence.Predicting evolution by in vitro evolution requires determining evolutionary pathways.Combining computational and experimental screening for rapid optimization of protein propertiesPredicting evolutionary potential: in vitro evolution accurately reproduces natural evolution of the tem beta-lactamase.Overcoming antigenic diversity and improving vaccines using DNA shuffling and screening technologies.Evolution of new nonantibody proteins via iterative somatic hypermutation.Engineering delta 9-16:0-acyl carrier protein (ACP) desaturase specificity based on combinatorial saturation mutagenesis and logical redesign of the castor delta 9-18:0-ACP desaturase.Enhancement of reporter gene detection sensitivity by insertion of specific mini-peptide-coding sequencesDiversity of nitrile hydratase and amidase enzyme genes in Rhodococcus erythropolis recovered from geographically distinct habitats.The optimal burst of mutation to create a phenotype.Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin.ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.Population dynamics simulations of functional model proteins.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Protein evolution by molecular breeding.
@ast
Protein evolution by molecular breeding.
@en
type
label
Protein evolution by molecular breeding.
@ast
Protein evolution by molecular breeding.
@en
prefLabel
Protein evolution by molecular breeding.
@ast
Protein evolution by molecular breeding.
@en
P1476
Protein evolution by molecular breeding.
@en
P2093
Minshull J
Stemmer WP
P304
P356
10.1016/S1367-5931(99)80044-1
P577
1999-06-01T00:00:00Z