Directed evolution of a recombinase for improved genomic integration at a native human sequence.
about
Chimeric recombinases with designed DNA sequence recognitionGene therapy for severe combined immunodeficiency: are we there yet?Phage integrases for the construction and manipulation of transgenic mammalsExpanding the scope of site-specific recombinases for genetic and metabolic engineeringAttachment site recognition and regulation of directionality by the serine integrasesMutants of Cre recombinase with improved accuracyMutational analysis of highly conserved residues in the phage phiC31 integrase reveals key amino acids necessary for the DNA recombinationLaboratory-directed protein evolutionDirected evolution: an approach to engineer enzymes.A look to future directions in gene therapy research for monogenic diseases.DAXX interacts with phage PhiC31 integrase and inhibits recombination.Directed evolution of recombinase specificity by split gene reassemblyMutational derivatives of PhiC31 integrase with increased efficiency and specificity.Hybrid lentivirus-phiC31-int-NLS vector allows site-specific recombination in murine and human cells but induces DNA damage.Utilizing natural diversity to evolve protein function: applications towards thermostability.Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells.Enhancement of plasmid-mediated gene therapy for muscular dystrophy by directed plasmid integration.Serine integrase chimeras with activity in E. coli and HeLa cells.Current advances in retroviral gene therapy.Regulated gene insertion by steroid-induced PhiC31 integrase.A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cellsViral vectors: from virology to transgene expressionA programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cellsImproved site-specific recombinase-based method to produce selectable marker- and vector-backbone-free transgenic cells.Cross-talk between diverse serine integrases.Intragenic integration in DLC1 sustains factor VIII expression in primary human cells without insertional oncogenicity.Enhancing the specificity of recombinase-mediated genome engineering through dimer interface redesign.Recombinase technology: applications and possibilitiesExogenous enzymes upgrade transgenesis and genetic engineering of farm animals.Genome Editing Techniques and Their Therapeutic Applications.Screening of potential pseudo att sites of Streptomyces phage ΦC31 integrase in the human genome.Evolution of variants of yeast site-specific recombinase Flp that utilize native genomic sequences as recombination target sites.Selection of bacteriophage lambda integrases with altered recombination specificity by in vitro compartmentalization.Phage TP901-1 site-specific integrase functions in human cellsRecombinase mediated cassette exchange into genomic targets using an adenovirus vector.Zinc-finger recombinase activities in vitro.Stable nonviral genetic correction of inherited human skin disease.Engineering altered protein-DNA recognition specificity.
P2860
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P2860
Directed evolution of a recombinase for improved genomic integration at a native human sequence.
description
2001 nî lūn-bûn
@nan
2001 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Directed evolution of a recomb ...... on at a native human sequence.
@ast
Directed evolution of a recomb ...... on at a native human sequence.
@en
Directed evolution of a recomb ...... on at a native human sequence.
@nl
type
label
Directed evolution of a recomb ...... on at a native human sequence.
@ast
Directed evolution of a recomb ...... on at a native human sequence.
@en
Directed evolution of a recomb ...... on at a native human sequence.
@nl
prefLabel
Directed evolution of a recomb ...... on at a native human sequence.
@ast
Directed evolution of a recomb ...... on at a native human sequence.
@en
Directed evolution of a recomb ...... on at a native human sequence.
@nl
P2093
P2860
P356
P1476
Directed evolution of a recomb ...... on at a native human sequence.
@en
P2093
B Thyagarajan
C R Sclimenti
P2860
P304
P356
10.1093/NAR/29.24.5044
P407
P577
2001-12-01T00:00:00Z