Engineering delta 9-16:0-acyl carrier protein (ACP) desaturase specificity based on combinatorial saturation mutagenesis and logical redesign of the castor delta 9-18:0-ACP desaturase.
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Key enzymes catalyzing glycerol to 1,3-propanediolThe crystal structure of the ivy Delta4-16:0-ACP desaturase reveals structural details of the oxidized active site and potential determinants of regioselectivityStructure-oriented substrate specificity engineering of aldehyde-deformylating oxygenase towards aldehydes carbon chain lengthStructure-function relationships in plant phenylpropanoid biosynthesisGene characterized for membrane desaturase that produces (E)-11 isomers of mono- and diunsaturated fatty acids.Combining computational and experimental screening for rapid optimization of protein propertiesImproving the thermostability of alpha-amylase by combinatorial coevolving-site saturation mutagenesis.Modulating seed beta-ketoacyl-acyl carrier protein synthase II level converts the composition of a temperate seed oil to that of a palm-like tropical oilOil biosynthesis in a basal angiosperm: transcriptome analysis of Persea Americana mesocarpA single mutation in the castor Delta9-18:0-desaturase changes reaction partitioning from desaturation to oxidase chemistry.Polyunsaturated fatty acids: biotechnology.Revealing the catalytic potential of an acyl-ACP desaturase: tandem selective oxidation of saturated fatty acids.Membrane synthesis, specific lipid requirements, and localized lipid composition changes associated with a positive-strand RNA virus RNA replication proteinSynthetic redesign of plant lipid metabolism.Desaturases: emerging models for understanding functional diversification of diiron-containing enzymes.Metabolic engineering of plant oils and waxes for use as industrial feedstocks.Desaturation and hydroxylation. Residues 148 and 324 of Arabidopsis FAD2, in addition to substrate chain length, exert a major influence in partitioning of catalytic specificity.A multifunctional acyl-acyl carrier protein desaturase from Hedera helix L. (English ivy) can synthesize 16- and 18-carbon monoene and diene products.Alteration of chain length substrate specificity of Aeromonas caviae R-enantiomer-specific enoyl-coenzyme A hydratase through site-directed mutagenesis.Mechanistic and structural insights into the regioselectivity of an acyl-CoA fatty acid desaturase via directed molecular evolutionElimination of 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation.Metabolic engineering of seeds can achieve levels of omega-7 fatty acids comparable with the highest levels found in natural plant sources.Transcriptional Activation of Two Delta-9 Palmitoyl-ACP Desaturase Genes by MYB115 and MYB118 Is Critical for Biosynthesis of Omega-7 Monounsaturated Fatty Acids in the Endosperm of Arabidopsis Seeds.Overexpression of MYB115, AAD2, or AAD3 in Arabidopsis thaliana seeds yields contrasting omega-7 contents.Biological chemistry: enzymes in focus.Changing the specificity of α-amino acid ester hydrolase toward para-hydroxyl cephalosporins synthesis by site-directed saturation mutagenesis.Two distinct domains contribute to the substrate acyl chain length selectivity of plant acyl-ACP thioesterase.Survey of protein engineering strategiesHalf-of-the-Sites Reactivity of the Castor Δ9-18:0-Acyl Carrier Protein Desaturase
P2860
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P2860
Engineering delta 9-16:0-acyl carrier protein (ACP) desaturase specificity based on combinatorial saturation mutagenesis and logical redesign of the castor delta 9-18:0-ACP desaturase.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Engineering delta 9-16:0-acyl ...... r delta 9-18:0-ACP desaturase.
@en
type
label
Engineering delta 9-16:0-acyl ...... r delta 9-18:0-ACP desaturase.
@en
prefLabel
Engineering delta 9-16:0-acyl ...... r delta 9-18:0-ACP desaturase.
@en
P2860
P356
P1476
Engineering delta 9-16:0-acyl ...... r delta 9-18:0-ACP desaturase.
@en
P2093
P2860
P304
21500-21505
P356
10.1074/JBC.M102129200
P407
P577
2001-04-09T00:00:00Z