Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal.
about
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathwayHuman mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsHighly expressed proteins have an increased frequency of alanine in the second amino acid position.Inhibition of the methionine aminopeptidase 2 enzyme for the treatment of obesityAntibiotic Activity and Characterization of BB-3497, a Novel Peptide Deformylase InhibitorCrystal structure of type II peptide deformylase from Staphylococcus aureusPyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1Pyridinylquinazolines Selectively Inhibit Human Methionine Aminopeptidase-1 in CellsN-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo.Peptide methionine sulfoxide reductase from Escherichia coli and Mycobacterium tuberculosis protects bacteria against oxidative damage from reactive nitrogen intermediatesUnlocking the proteomic information encoded in MALDI-TOF-MS data used for microbial identification and characterization.Development and validation of a whole-cell inhibition assay for bacterial methionine aminopeptidase by surface-enhanced laser desorption ionization-time of flight mass spectrometryPeptide deformylase as a target for new generation, broad spectrum antimicrobial agents.Amino-terminal extension present in the methionine aminopeptidase type 1c of Mycobacterium tuberculosis is indispensible for its activity.Inhibition of human peptide deformylase disrupts mitochondrial functionExpression of Escherichia coli methionyl-tRNA formyltransferase in Saccharomyces cerevisiae leads to formylation of the cytoplasmic initiator tRNA and possibly to initiation of protein synthesis with formylmethionine.Mutations at the S1 sites of methionine aminopeptidases from Escherichia coli and Homo sapiens reveal the residues critical for substrate specificity.Peptide deformylase: a target for novel antibiotics?Control of protein life-span by N-terminal methionine excisionThe crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.Impact of the N-terminal amino acid on targeted protein degradation.Overexpression of peptide deformylase in breast, colon, and lung cancers.Identification of crucial amino acids of bacterial Peptide deformylases affecting enzymatic activity in response to oxidative stressPeptide deformylase inhibitors as potent antimycobacterial agents.Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targetsStructural analysis of inhibition of Mycobacterium tuberculosis methionine aminopeptidase by bengamide derivatives.Analogs of N'-hydroxy-N-(4H,5H-naphtho[1,2-d]thiazol-2-yl)methanimidamide inhibit Mycobacterium tuberculosis methionine aminopeptidases.Application of high-precision isotope ratio monitoring mass spectrometry to identify the biosynthetic origins of proteinsShine-Dalgarno interaction prevents incorporation of noncognate amino acids at the codon following the AUGIn Vitro Gene Silencing of the Fish Microsporidian Heterosporis saurida by RNA Interference.Post-translation modification in Archaea: lessons from Haloferax volcanii and other haloarchaea.Co-expression for intracellular processing in microbial protein production.N-terminomics and proteogenomics, getting off to a good start.Formyl-methionine as a degradation signal at the N-termini of bacterial proteins.Proteome-wide analysis of the amino terminal status of Escherichia coli proteins at the steady-state and upon deformylation inhibition.Peptide deformylase as an antibacterial drug target: assays for detection of its inhibition in Escherichia coli cell homogenates and intact cells.Peptide deformylase as an antibacterial drug target: target validation and resistance development.Subinhibitory concentrations of the deformylase inhibitor actinonin increase bacterial release of neutrophil-activating peptides: a new approach to antimicrobial chemotherapy.Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.
P2860
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P2860
Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal.
description
1999 nî lūn-bûn
@nan
1999 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Processing of the N termini of ...... n prior to methionine removal.
@ast
Processing of the N termini of ...... n prior to methionine removal.
@en
type
label
Processing of the N termini of ...... n prior to methionine removal.
@ast
Processing of the N termini of ...... n prior to methionine removal.
@en
prefLabel
Processing of the N termini of ...... n prior to methionine removal.
@ast
Processing of the N termini of ...... n prior to methionine removal.
@en
P2093
P356
P1476
Processing of the N termini of ...... n prior to methionine removal.
@en
P2093
A Chapman-Smith
C G Miller
J E Cronan
J L Miller
J Solbiati
P304
P356
10.1006/JMBI.1999.2913
P407
P577
1999-07-01T00:00:00Z