An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway
about
Identification and analysis of the acetylated status of poplar proteins reveals analogous N-terminal protein processing mechanisms with other eukaryotesHuman mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibioticsAmine-synthesizing enzyme N-substituted formamide deformylase: screening, purification, characterization, and gene cloningMutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translationN-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effectsStructure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer TargetUnderstanding the highly efficient catalysis of prokaryotic peptide deformylases by shedding light on the determinants specifying the low activity of the human counterpartHigh-throughput identification of inhibitors of human mitochondrial peptide deformylase.System for expression of microsporidian methionine amino peptidase type 2 (MetAP2) in the yeast Saccharomyces cerevisiaeSolvent-assisted slow conversion of a dithiazole derivative produces a competitive inhibitor of peptide deformylase.Inhibition of human peptide deformylase disrupts mitochondrial functionInvestigational antimicrobial agents of 2013.The crystal structure of mitochondrial (Type 1A) peptide deformylase provides clear guidelines for the design of inhibitors specific for the bacterial forms.Impact of the N-terminal amino acid on targeted protein degradation.Overexpression of peptide deformylase in breast, colon, and lung cancers.Peptide deformylase inhibitors as potent antimycobacterial agents.An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase.Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.Therapeutic potential of peptide deformylase inhibitors.Zinc is the metal cofactor of Borrelia burgdorferi peptide deformylase.Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation.Delineation of alternative conformational states in Escherichia coli peptide deformylase via thermodynamic studies for the binding of actinonin.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Peptide deformylase--a promising therapeutic target for tuberculosis and antibacterial drug discovery.Metalloproteomics, metalloproteomes, and the annotation of metalloproteins.Metalloenzyme inhibitors for the treatment of Gram-negative bacterial infections: a patent review (2009-2012).New roles for mitochondrial proteases in health, ageing and disease.Identification of benzofuran-4,5-diones as novel and selective non-hydroxamic acid, non-peptidomimetic based inhibitors of human peptide deformylase.Expression, purification, and activity assay of peptide deformylase from Escherichia coli and Staphylococcus aureus.The C-terminal residue of phage Vp16 PDF, the smallest peptide deformylase, acts as an offset element locking the active conformation.A new synthetic route to N-benzyl carboxamides through the reverse reaction of N-substituted formamide deformylase.Phylogenomic and biochemical characterization of three Legionella pneumophila polypeptide deformylases.Type 3 peptide deformylases are required for oxidative phosphorylation in Trypanosoma brucei.Successful COG8 and PDF overlap is mediated by alterations in splicing and polyadenylation signals.The C. elegans methionine aminopeptidase 2 analog map-2 is required for germ cell proliferation.Functional and developmental impact of cytosolic protein N-terminal methionine excision in Arabidopsis.Yeast glutamine-fructose-6-phosphate aminotransferase (Gfa1) requires methionine aminopeptidase activity for proper function.Interplay between N-terminal methionine excision and FtsH protease is essential for normal chloroplast development and function in Arabidopsis.
P2860
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P2860
An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
An unusual peptide deformylase ...... al methionine excision pathway
@ast
An unusual peptide deformylase ...... al methionine excision pathway
@en
An unusual peptide deformylase ...... al methionine excision pathway
@en-gb
An unusual peptide deformylase ...... al methionine excision pathway
@nl
type
label
An unusual peptide deformylase ...... al methionine excision pathway
@ast
An unusual peptide deformylase ...... al methionine excision pathway
@en
An unusual peptide deformylase ...... al methionine excision pathway
@en-gb
An unusual peptide deformylase ...... al methionine excision pathway
@nl
prefLabel
An unusual peptide deformylase ...... al methionine excision pathway
@ast
An unusual peptide deformylase ...... al methionine excision pathway
@en
An unusual peptide deformylase ...... al methionine excision pathway
@en-gb
An unusual peptide deformylase ...... al methionine excision pathway
@nl
P2093
P2860
P921
P3181
P356
P1476
An unusual peptide deformylase ...... al methionine excision pathway
@en
P2093
Alessandro Sardini
Alexandre Serero
Juan Martinez-Sanz
P2860
P304
P3181
P356
10.1074/JBC.M309770200
P407
P577
2003-12-26T00:00:00Z