Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.
about
Antibiotics and bacterial resistance in the 21st century.Safety, tolerability, and efficacy of GSK1322322 in the treatment of acute bacterial skin and skin structure infections.Microbiome changes in healthy volunteers treated with GSK1322322, a novel antibiotic targeting bacterial peptide deformylase.Structural basis for the inhibition of M1 family aminopeptidases by the natural product actinonin: Crystal structure in complex with E. coli aminopeptidase N.Reversing resistance: The next generation antibacterials.Structure-Based Drug Design of Small Molecule Peptide Deformylase Inhibitors to Treat Cancer.A unique peptide deformylase platform to rationally design and challenge novel active compounds.Potent sub-MIC effect of GSK1322322 and other peptide deformylase inhibitors on in vitro growth of Staphylococcus aureus.Penetration of GSK1322322 into epithelial lining fluid and alveolar macrophages as determined by bronchoalveolar lavageEmerging drugs on methicillin-resistant Staphylococcus aureus.Reducing antibacterial development risk for GSK1322322 by exploring potential human dose regimens in nonclinical efficacy studies using immunocompetent rats.Pharmacokinetics/Pharmacodynamics of Peptide Deformylase Inhibitor GSK1322322 against Streptococcus pneumoniae, Haemophilus influenzae, and Staphylococcus aureus in Rodent Models of Infection.Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.In vitro and intracellular activities of peptide deformylase inhibitor GSK1322322 against Legionella pneumophila isolatesLigand and Structure-Based Approaches for the Identification of Peptide Deformylase Inhibitors as Antibacterial Drugs.Safety, tolerability, and pharmacokinetics of oral and intravenous administration of GSK1322322, a peptide deformylase inhibitor.Virtual Screening Approach of Bacterial Peptide Deformylase Inhibitors Results in New Antibiotics.High-throughput analysis of Yersinia pseudotuberculosis gene essentiality in optimised in vitro conditions, and implications for the speciation of Yersinia pestis.
P2860
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P2860
Comparative analysis of the antibacterial activity of a novel peptide deformylase inhibitor, GSK1322322.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Comparative analysis of the an ...... rmylase inhibitor, GSK1322322.
@en
type
label
Comparative analysis of the an ...... rmylase inhibitor, GSK1322322.
@en
prefLabel
Comparative analysis of the an ...... rmylase inhibitor, GSK1322322.
@en
P2093
P2860
P356
P1476
Comparative analysis of the an ...... rmylase inhibitor, GSK1322322.
@en
P2093
Daryl Hoban
Deborah Butler
Donghui Qin
Karen O'Dwyer
Kelly Aubart
Magdalena Zalacain
Meredith Hackel
Samuel Bouchillon
Sarah Hightower
P2860
P304
P356
10.1128/AAC.02566-12
P407
P577
2013-03-11T00:00:00Z