2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
about
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replicationChemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promisingRole of DNA-dependent protein kinase catalytic subunit in cancer development and treatmentInhibition of non-homologous end joining repair impairs pancreatic cancer growth and enhances radiation responsePICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathwayActivation of DNA damage repair pathways in response to nitrogen mustard-induced DNA damage and toxicity in skin keratinocytes.Small molecules enhance CRISPR genome editing in pluripotent stem cells.A new arylbenzofuran derivative functions as an anti-tumour agent by inducing DNA damage and inhibiting PARP activity.The life and death of DNA-PK.Antiproliferative activity of novel thiopyran analogs on MCF-7 breast and HCT-15 colon cancer cells: synthesis, cytotoxicity, cell cycle analysis, and DNA-binding.Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.The N-terminal region of the DNA-dependent protein kinase catalytic subunit is required for its DNA double-stranded break-mediated activation.Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors.PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatinInhibition of the heat shock response by PI103 enhances the cytotoxicity of arsenic trioxide.The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer.Radiosensitizing activity of a novel Benzoxazine through the promotion of apoptosis and inhibition of DNA repair.Obligate ligation-gated recombination (ObLiGaRe): custom-designed nuclease-mediated targeted integration through nonhomologous end joining.Targeting DNA-Dependent Protein Kinase for Cancer Therapy.DNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism.Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond.Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts.ATM activation accompanies histone H2AX phosphorylation in A549 cells upon exposure to tobacco smoke.Homologous recombination is required for AAV-mediated gene targeting.ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells.
P2860
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P2860
2,6-disubstituted pyran-4-one and thiopyran-4-one inhibitors of DNA-Dependent protein kinase (DNA-PK).
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@ast
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@en
type
label
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@ast
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@en
prefLabel
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@ast
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@en
P2093
P1476
2,6-disubstituted pyran-4-one ...... ndent protein kinase (DNA-PK).
@en
P2093
Bernard T Golding
Caroline Richardson
Graeme C M Smith
Ian R Hardcastle
Jonathan J Hollick
Laurent J M Rigoreau
Niall Martin
Roger J Griffin
P304
P356
10.1016/S0960-894X(03)00652-8
P407
P577
2003-09-01T00:00:00Z