about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinThe novel membrane protein TMEM59 modulates complex glycosylation, cell surface expression, and secretion of the amyloid precursor proteinPresenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formationPro-domain removal in ASP-2 and the cleavage of the amyloid precursor are influenced by pHThe role of APP and BACE1 trafficking in APP processing and amyloid-β generationGolgi defects enhance APP amyloidogenic processing in Alzheimer's diseaseCrystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein ProductionTrafficking and proteolytic processing of APPBACE1 expression and activity: relevance in Alzheimer's diseasePhenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cellsAlzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid raftsThe normal and pathologic roles of the Alzheimer's β-secretase, BACE1Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing.Characterization of the glycosylation profiles of Alzheimer's beta -secretase protein Asp-2 expressed in a variety of cell lines.Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology.Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.A splice variant of beta-secretase deficient in the amyloidogenic processing of the amyloid precursor protein.Altered proteolysis in fibroblasts of Alzheimer patients with predictive implications for subjects at risk of diseaseFunction, therapeutic potential and cell biology of BACE proteases: current status and future prospects.Determination of the proteolytic cleavage sites of the amyloid precursor-like protein 2 by the proteases ADAM10, BACE1 and γ-secretase.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.Beta-secretase: structure, function, and evolution.Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process.Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Advances with RNA interference in Alzheimer's disease research.Alzheimer's disease beta-amyloid peptides are released in association with exosomes.Beta-secretase as a target for the treatment of Alzheimer's disease.Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagyBeta-secretase activity increases with aging in human, monkey, and mouse brain.Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.Aspartic proteases involved in Alzheimer's disease.ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1Prion protein interacts with BACE1 protein and differentially regulates its activity toward wild type and Swedish mutant amyloid precursor protein.The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer's disease animal modelPathogenic factors in vascular dementia and Alzheimer's disease. Multiple actions of heparin that probably are beneficial.BACE2 expression increases in human neurodegenerative disease.Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme.The Alzheimer's disease beta-secretase enzyme, BACE1.Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor proteinProteolytic Processing of Neuregulin 1 Type III by Three Intramembrane-cleaving Proteases
P2860
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P2860
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Maturation and pro-peptide cleavage of beta-secretase.
@ast
Maturation and pro-peptide cleavage of beta-secretase.
@en
type
label
Maturation and pro-peptide cleavage of beta-secretase.
@ast
Maturation and pro-peptide cleavage of beta-secretase.
@en
prefLabel
Maturation and pro-peptide cleavage of beta-secretase.
@ast
Maturation and pro-peptide cleavage of beta-secretase.
@en
P2093
P356
P1476
Maturation and pro-peptide cleavage of beta-secretase.
@en
P2093
Multhaup G
P304
30849-30854
P356
10.1074/JBC.M003202200
P407
P577
2000-10-01T00:00:00Z