Advances in the use of synthetic combinatorial chemistry: mixture-based libraries. - Wikidata - awgldk - TriplyDB

Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

http://www.wikidata.org/entity/Q30878526

about

Shifting from the single to the multitarget paradigm in drug discovery Identification of a small molecule that selectively inhibits mouse PC2 over mouse PC1/3: a computational and experimental study Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure.Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches.SERS assisted ultra-fast peptidic screening: a new tool for drug discovery.Combinatorial synthesis of benztropine libraries and their evaluation as monoamine transporter inhibitors.Identification of NCAM-binding peptides promoting neurite outgrowth via a heterotrimeric G-protein-coupled pathway.Conformation-opioid activity relationships of bicyclic guanidines from 3D similarity analysis.The pharmacological properties of a novel MCH1 receptor antagonist isolated from combinatorial libraries.Chemoinformatic analysis of combinatorial libraries, drugs, natural products, and molecular libraries small molecule repository.Identification, structure-activity relationships and molecular modeling of potent triamine and piperazine opioid ligands.De Novo Modular Development of a Foldameric Protein-Protein Interaction Inhibitor for Separate Hot Spots: A Dynamic Covalent Assembly Approach.Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.Integrating computational and mixture-based screening of combinatorial libraries.A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs).Estimation of affinities of ligands in mixtures via magnetic recovery of target-ligand complexes and chromatographic analyses: chemometrics and an experimental model.Inhibitor screening of proprotein convertases using positional scanning libraries.Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.Generation of diverse 1-imidazolylisoquinolines via silver triflate-catalyzed reaction of 2-alkynylbenzaldoxime with imidazole.Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries Discovery of novel inhibitors of a disintegrin and metalloprotease 17 (ADAM17) using glycosylated and non-glycosylated substrates.Facile one-step coating approach to magnetic submicron particles with poly(ethylene glycol) coats and abundant accessible carboxyl groups The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries.Libraries from Libraries: A Series of Sulfonamide Linked Heterocycles Derived from the Same Scaffold.Site-specific Labeling of a Protein Lysine Residue By Novel Kinetic Labeling Combinatorial Libraries.Identification of Small Molecule Inhibitors of Human As(III) S-Adenosylmethionine Methyltransferase (AS3MT)Peptides and Peptide Analogs to Inhibit Protein-Protein Interactions.Discovery of Mixed Pharmacology Melanocortin-3 Agonists and Melanocortin-4 Receptor Tetrapeptide Antagonist Compounds (TACOs) Based on the Sequence Ac-Xaa1-Arg-(pI)DPhe-Xaa4-NH2.Template-induced macrocycle diversity through large ring-forming alkylations of tryptophan.Synergy and antagonism of promiscuous inhibition in multiple-compound mixtures.Identification of hexapeptides that render C2 myoblasts the resistant to menadione‐induced cell death

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Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

http://www.wikidata.org/entity/Q30878526

description

2003 nî lūn-bûn

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2003 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2003 թվականի հունվարին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

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Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

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Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

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Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

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Nature Medicine

P1476

Advances in the use of synthetic combinatorial chemistry: mixture-based libraries.

@en

P2093

Clemencia Pinilla

http://www.w3.org/2001/XMLSchema#string

Eva Borràs

http://www.w3.org/2001/XMLSchema#string

Jon R Appel

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Richard A Houghten

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P2860

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE)

A priori delineation of a peptide which mimics a discontinuous antigenic determinant

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

Identification of MHC class II-restricted peptide ligands, including a glutamic acid decarboxylase 65 sequence, that stimulate diabetogenic T cells from transgenic BDC2.5 nonobese diabetic mice.

Contribution of individual amino acids within MHC molecule or antigenic peptide to TCR ligand potency.

Combinatorial chemistry toward understanding the function(s) of carbohydrates and carbohydrate conjugates.

Combinatorial peptide libraries and biometric score matrices permit the quantitative analysis of specific and degenerate interactions between clonotypic TCR and MHC peptide ligands.

Definition of the extended substrate specificity determinants for beta-tryptases I and II.

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118-122

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10.1038/NM0103-118

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1

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10961669

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1024852559

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12514724

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