A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.

A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.

Item
http://www.wikidata.org/entity/Q30878761
Shifting from the single to the multitarget paradigm in drug discoveryBlockade of neuronal α7-nAChR by α-conotoxin ImI explained by computational scanning and energy calculationsIntegrating computational and mixture-based screening of combinatorial libraries.A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit.Oxidative folding and preparation of α-conotoxins for use in high-throughput structure-activity relationship studies.Discovery of a potent and selective α3β4 nicotinic acetylcholine receptor antagonist from an α-conotoxin synthetic combinatorial library.Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.Incorporation of post-translational modified amino acids as an approach to increase both chemical and biological diversity of conotoxins and conopeptides.Natural compounds interacting with nicotinic acetylcholine receptors: from low-molecular weight ones to peptides and proteins.Advances in venomics.High-throughput production of two disulphide-bridge toxins.Exocyclic control of turn induction in macrocyclic peptide scaffolds.
P2860

A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists.

Item
http://www.wikidata.org/entity/Q30878761
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
name
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@ast
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@en
type
label
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@ast
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@en
prefLabel
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@ast
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
A synthetic combinatorial stra ...... lcholine receptor antagonists.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932