Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
about
beta-Amyloid degradation and Alzheimer's diseaseAlternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondriaA capillary electrophoresis method for evaluation of Abeta proteolysis in vitroInsulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivoReduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 alleleYeast Ste23p shares functional similarities with mammalian insulin-degrading enzymes.Ste24p Mediates Proteolysis of Both Isoprenylated and Non-prenylated Oligopeptides.Statins promote the degradation of extracellular amyloid {beta}-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretionBiochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life.Mechanisms of enzymatic degradation of amyloid Beta microfibrils generating nanofilaments and nanospheres related to cytotoxicity.17β-Estradiol regulates insulin-degrading enzyme expression via an ERβ/PI3-K pathway in hippocampus: relevance to Alzheimer's preventionDisorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.Brain estrogen deficiency accelerates Abeta plaque formation in an Alzheimer's disease animal model.Catalytic immunoglobulin gene delivery in a mouse model of Alzheimer's disease: prophylactic and therapeutic applications.Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.Identification and quantification of amyloid beta-related peptides in human plasma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.Overexpression of Insulin Degrading Enzyme could Greatly Contribute to Insulin Down-regulation Induced by Short-Term Swimming Exercise.Is the distinction between Alzheimer's disease and vascular dementia possible and relevant?Specific amyloid β clearance by a catalytic antibody construct.Metal-dependent amyloid β-degrading catalytic antibody construct.17β-estradiol and progesterone regulate expression of β-amyloid clearance factors in primary neuron cultures and female rat brainCurrent concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease.Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairmentChronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.Current experimental therapy for Alzheimer's diseaseRegulation of beta-amyloid levels in the brain of cholesterol-fed rabbit, a model system for sporadic Alzheimer's diseaseAβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.Clearance of cerebral Aβ in Alzheimer's disease: reassessing the role of microglia and monocytes.Protein kinase C-regulated aβ production and clearance.Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease.Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate.Activators and inhibitors of the plasminogen system in Alzheimer's disease.Proteases and glycosidases on the surface of exosomes: Newly discovered mechanisms for extracellular remodeling.Neprilysin in the cerebrospinal fluid and serum of patients infected with HIV1- subtypes C and B.Resveratrol Sustains Insulin-Degrading Enzyme Activity toward Aβ42
P2860
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P2860
Insulysin hydrolyzes amyloid beta peptides to products that are neither neurotoxic nor deposit on amyloid plaques.
description
2000 nî lūn-bûn
@nan
2000 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Insulysin hydrolyzes amyloid b ...... or deposit on amyloid plaques.
@ast
Insulysin hydrolyzes amyloid b ...... or deposit on amyloid plaques.
@en
type
label
Insulysin hydrolyzes amyloid b ...... or deposit on amyloid plaques.
@ast
Insulysin hydrolyzes amyloid b ...... or deposit on amyloid plaques.
@en
prefLabel
Insulysin hydrolyzes amyloid b ...... or deposit on amyloid plaques.
@ast
Insulysin hydrolyzes amyloid b ...... or deposit on amyloid plaques.
@en
P2093
P1476
Insulysin hydrolyzes amyloid b ...... nor deposit on amyloid plaques
@en
P2093
A Mukherjee
J P Goodman
M Kihiko-Ehmann
P304
P356
10.1523/JNEUROSCI.20-23-08745.2000
P407
P577
2000-12-01T00:00:00Z