Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.
about
Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve AgentsGrowth of Escherichia coli coexpressing phosphotriesterase and glycerophosphodiester phosphodiesterase, using paraoxon as the sole phosphorus source.Directed evolution of an extremely fast phosphotriesterase by in vitro compartmentalization.The role of nonbonded interactions in the conformational dynamics of organophosphorous hydrolase adsorbed onto functionalized mesoporous silica surfaces.Enhanced refoldability and thermoactivity of fluorinated phosphotriesterase.Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesteraseRedesigning Aldolase Stereoselectivity by Homologous Grafting.Microbial degradation of organophosphorus compounds.Conformational variability of organophosphorus hydrolase upon soman and paraoxon binding.Monobody-mediated alteration of enzyme specificityMolecular dynamics simulations of the detoxification of paraoxon catalyzed by phosphotriesterase.Organophosphorus hydrolase as an in vivo catalytic nerve agent bioscavenger.Catalytic mechanisms for phosphotriesterasesCurrent and emerging strategies for organophosphate decontamination: special focus on hyperstable enzymes.Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.Exploring stereochemical specificity of phosphotriesterase by MM-PBSA and MM-GBSA calculation and steered molecular dynamics simulation.Update on biochemical properties of recombinant Pseudomonas diminuta phosphotriesterase.Differentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents.Contribution of the active-site metal cation to the catalytic activity and to the conformational stability of phosphotriesterase: temperature- and pH-dependence.Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesteraseA molecular mechanism of enantiorecognition of tertiary alcohols by carboxylesterases.An isofenphos-methyl hydrolase (Imh) capable of hydrolyzing the P-O-Z moiety of organophosphorus pesticides containing an aryl or heterocyclic group.Stereoselectivity of phosphotriesterase with paraoxon derivatives: a computational study.Survey of protein engineering strategiesMutation of outer-shell residues modulates metal ion co-ordination strength in a metalloenzymeDetoxication of Anticholinesterase Pesticides
P2860
Q27670790-4BD03D55-16DF-4A6A-BA73-0869250A1134Q31034833-794DD095-1321-467E-A6AE-8F2E1AEB151BQ31123054-CB6C9AAB-4BD5-4F8D-9564-B8DC07E22098Q33638338-A7064909-F497-42F6-82A4-3E5F968FA968Q33944563-A467B527-4EA3-41FA-BE1C-3867EFB2BAD3Q34156286-F08B9FCB-1C72-4CA8-9590-A268F9FC9C00Q36057720-EBD70485-2636-45AF-B8B0-428863AFD1DFQ36440563-31E5B9EE-E434-477C-A6DF-257A37CA11ADQ36546322-37A94549-C196-4EAD-9804-5E46676DCAAFQ37186769-EB2EEB3E-8BE4-40E3-B379-8CAAEEAFEA42Q37368984-9D275EB7-FFED-4FB4-969A-C69BC740E049Q37989116-431932A7-4C78-4F01-886A-BCF0A4844BDFQ38007798-39DBD23C-734D-486B-88C1-20D15ECA7D5FQ38718707-3845C377-CF01-4065-9399-D8ADE00BEF0BQ39004225-A3E751BB-E3DF-4F62-A144-53028675D6EEQ39630932-04831919-C3D4-4E33-976E-372F72D784CCQ39968681-3D865E3B-DEAD-4599-A29E-F5C23D5E5C7BQ40320058-230C8FC4-A5F6-4046-80E4-E93202D8594DQ42284276-425D0EDD-B117-4C26-AD63-B5D74F38E387Q42419073-D07C2875-2365-4A63-8181-E281087867D0Q44470616-0B47CAF6-C3C7-4317-A053-FCBCCD433268Q45069989-434D5621-5007-4A18-9DC8-55BF0EFF0DFDQ52801251-BF799962-C0CA-43C5-A2D4-7606F12ADF84Q56895981-70D5A8E4-1F32-4876-9DF8-11D54E3A0E8AQ56896955-2024713A-1A26-4599-BB16-875C57D6B22FQ57201890-77704061-4293-4061-B55E-01370B3F02A0
P2860
Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
name
Enhancement, relaxation, and r ...... ution of active site residues.
@ast
Enhancement, relaxation, and r ...... ution of active site residues.
@en
type
label
Enhancement, relaxation, and r ...... ution of active site residues.
@ast
Enhancement, relaxation, and r ...... ution of active site residues.
@en
prefLabel
Enhancement, relaxation, and r ...... ution of active site residues.
@ast
Enhancement, relaxation, and r ...... ution of active site residues.
@en
P2093
P356
P1433
P1476
Enhancement, relaxation, and r ...... ution of active site residues.
@en
P2093
Chen-Goodspeed M
Raushel FM
P304
P356
10.1021/BI001549D
P407
P577
2001-02-01T00:00:00Z