Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase - Wikidata - awgldk - TriplyDB

Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase

Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase

http://www.wikidata.org/entity/Q42419073

about

Enzymes for the Homeland Defense: Optimizing Phosphotriesterase for the Hydrolysis of Organophosphate Nerve Agents Characterisation of the organophosphate hydrolase catalytic activity of SsoPox Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template Structural characterization and function determination of a nonspecific carboxylate esterase from the amidohydrolase superfamily with a promiscuous ability to hydrolyze methylphosphonate esters Enzymatic neutralization of the chemical warfare agent VX: evolution of phosphotriesterase for phosphorothiolate hydrolysis.Structural determinants for the stereoselective hydrolysis of chiral substrates by phosphotriesterase Function discovery and structural characterization of a methylphosphonate esterase.Catalytic efficiencies of directly evolved phosphotriesterase variants with structurally different organophosphorus compounds in vitro.Promiscuity in the Enzymatic Catalysis of Phosphate and Sulfate Transfer.Catalytic mechanisms for phosphotriesterases Organophosphate-Hydrolyzing Enzymes as First-Line of Defence Against Nerve Agent-Poisoning: Perspectives and the Road Ahead.Cholinesterase reactivators and bioscavengers for pre- and post-exposure treatments of organophosphorus poisoning.Exploring stereochemical specificity of phosphotriesterase by MM-PBSA and MM-GBSA calculation and steered molecular dynamics simulation.High-throughput screening system based on phenolics-responsive transcription activator for directed evolution of organophosphate-degrading enzymes.The effect of conformational variability of phosphotriesterase upon N-acyl-L-homoserine lactone and paraoxon binding: insights from molecular dynamics studies.Stereoselectivity of phosphotriesterase with paraoxon derivatives: a computational study.Directed evolution of hydrolases for prevention of G-type nerve agent intoxication

P2860

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P2860

Stereoselective hydrolysis of organophosphate nerve agents by the bacterial phosphotriesterase

http://www.wikidata.org/entity/Q42419073

description

2010 nî lūn-bûn

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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@zh-cn

name

Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

@en

Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

@nl

type

label

Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

@en

Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

@nl

prefLabel

Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

@en

Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

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Stereoselective hydrolysis of ...... e bacterial phosphotriesterase

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P2093

Andrew Bigley

http://www.w3.org/2001/XMLSchema#string

C Linn Cadieux

http://www.w3.org/2001/XMLSchema#string

Douglas M Cerasoli

http://www.w3.org/2001/XMLSchema#string

Eman Ghanem

http://www.w3.org/2001/XMLSchema#string

Ping-Chuan Tsai

http://www.w3.org/2001/XMLSchema#string

Shane A Kasten

http://www.w3.org/2001/XMLSchema#string

Tony E Reeves

http://www.w3.org/2001/XMLSchema#string

Yingchun Li

http://www.w3.org/2001/XMLSchema#string

P2860

High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta

Balancing the stability and the catalytic specificities of OP hydrolases with enhanced V-agent activities

Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate

Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site.

Structural determinants of the substrate and stereochemical specificity of phosphotriesterase.

Enhancement, relaxation, and reversal of the stereoselectivity for phosphotriesterase by rational evolution of active site residues.

Resolution of chiral phosphate, phosphonate, and phosphinate esters by an enantioselective enzyme library.

Dissimilar plasmids isolated from Pseudomonas diminuta MG and a Flavobacterium sp. (ATCC 27551) contain identical opd genes.

Direct detection of stereospecific soman hydrolysis by wild-type human serum paraoxonase.

Differentiation of chiral phosphorus enantiomers by P and H NMR spectroscopy using amino acid derivatives as chemical solvating agents.

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7978-7987

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scholarly article

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10.1021/BI101056M

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37

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49

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Frank M Raushel

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2010-09-01T00:00:00Z

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45628224

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20701311

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organophosphate

stereoselectivity

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2945820

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