Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
about
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor proteinPotent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluationCrystal Structure of an Active Form of BACE1, an Enzyme Responsible for Amyloid Protein ProductionStructure-Based Design of Highly Selective β-Secretase Inhibitors: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Crystal StructurePhysiological Functions of the β-Site Amyloid Precursor Protein Cleaving Enzyme 1 and 2Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease.β-site amyloid precursor protein cleaving enzyme 1(BACE1) regulates Notch signaling by controlling the cleavage of Jagged 1 (Jag1) and Jagged 2 (Jag2) proteins.Inhibition of BACE1 for therapeutic use in Alzheimer's disease.BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's diseaseCapturing the essence of organic synthesis: from bioactive natural products to designed molecules in today's medicine.Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1.Aspartic proteases involved in Alzheimer's disease.Relevance of amyloid precursor-like protein 2 C-terminal fragments in pancreatic cancer cells.Genetic deletion of BACE1 in mice affects remyelination of sciatic nervesInhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Design of Potent and Highly Selective Inhibitors for Human β-Secretase 2 (Memapsin 1), a Target for Type 2 Diabetes.Structure-activity relationship of memapsin 2: implications on physiological functions and Alzheimer's diseasebeta-Secretase as a therapeutic target for Alzheimer's disease.Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.Cell biology, regulation and inhibition of beta-secretase (BACE-1).The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer's Disease and BeyondSmall-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).Subsite specificity of anthrax lethal factor and its implications for inhibitor developmentDimerization of beta-site beta-amyloid precursor protein-cleaving enzyme.Modulation of in vitro activity of zymogenic and mature recombinant human β-secretase by dietary plants.Structure-guided design of β-secretase (BACE-1) inhibitors.Prospects of β-Secretase Inhibitors for the Treatment of Alzheimer's Disease.
P2860
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P2860
Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta-secretase) inhibitor selectivity.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@ast
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@en
type
label
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@ast
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@en
prefLabel
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@ast
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@en
P2093
P356
P1433
P1476
Specificity of memapsin 1 and ...... retase) inhibitor selectivity.
@en
P2093
Arun K Ghosh
Chan Nguyen
Gerald Koelsch
Jeffrey A Loy
Jordan Tang
Robert T Turner
Thippeswamy Devasamudram
P304
P356
10.1021/BI025926T
P407
P577
2002-07-01T00:00:00Z