Cell biology, regulation and inhibition of beta-secretase (BACE-1).
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Protease regulation: the Yin and Yang of neural development and diseaseQuantitative assessment of the expanding complementarity between public and commercial databases of bioactive compoundsConformational Dynamics and Binding Free Energies of Inhibitors of BACE-1: From the Perspective of Protonation EquilibriaPhospho-eIF2α level is important for determining abilities of BACE1 reduction to rescue cholinergic neurodegeneration and memory defects in 5XFAD miceViable mouse gene ablations that robustly alter brain Aβ levels are rare.An overview of APP processing enzymes and products.A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic miceBiology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering.Adaptor protein 2-mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing.Curcumin: a natural substance with potential efficacy in Alzheimer's disease.MicroRNA implications across neurodevelopment and neuropathology.Application of computational methods for the design of BACE-1 inhibitors: validation of in silico modelling.Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions.Cholinergic modulation of amyloid precursor protein processing with emphasis on M1 muscarinic receptor: perspectives and challenges in treatment of Alzheimer's disease.Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).Recombinant pre-miR-29b for Alzheimer´s disease therapeutics.Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β-amyloid levels in the CNS.Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanismsThe transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathwayDesign and Synthesis of Novel Arylketo-containing P1-P3 Linked Macro-cyclic BACE-1 InhibitorsKlotho is a substrate for alpha-, beta- and gamma-secretaseModulation of in vitro activity of zymogenic and mature recombinant human β-secretase by dietary plants.Autophagosomes accumulation is associated with β-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats.Inhibition of P-glycoprotein facilitated glycosaminoglycan accumulation during chondrogenesis of human bone marrow mesenchymal stem cells
P2860
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P2860
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
description
article científic
@ca
article scientifique
@fr
articolo scientifico
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artigo científico
@pt
bilimsel makale
@tr
scientific article published on April 2009
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vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@en
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@nl
type
label
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@en
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@nl
prefLabel
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@en
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@nl
P2860
P1433
P1476
Cell biology, regulation and inhibition of beta-secretase (BACE-1).
@en
P2093
Anthony J Turner
Clare E Hunt
P2860
P304
P356
10.1111/J.1742-4658.2009.06929.X
P407
P577
2009-04-01T00:00:00Z