Synthesis and biological activities of novel 17-aminogeldanamycin derivatives. - Wikidata - awgldk - TriplyDB

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

http://www.wikidata.org/entity/Q31115482

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Functional and prognostic role of ZAP-70 in chronic lymphocytic leukaemia Lysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitro Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs.Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.The endoplasmic reticulum protein folding factory and its chaperones: new targets for drug discovery?The role of lysosomes in limiting drug toxicity in mice.Geldanamycin and Its Derivatives Inhibit the Growth of Myeloma Cells and Reduce the Expression of the MET Receptor.Heat shock protein 90 inhibitors in the treatment of cancer: current status and future directions Superparamagnetic iron oxide nanotheranostics for targeted cancer cell imaging and pH-dependent intracellular drug release.Intracellular Distribution-based Anticancer Drug Targeting: Exploiting a Lysosomal Acidification Defect Associated with Cancer Cells.Benzoquinone ansamycin 17AAG binds to mitochondrial voltage-dependent anion channel and inhibits cell invasion.Role for NAD(P)H:quinone oxidoreductase 1 and manganese-dependent superoxide dismutase in 17-(allylamino)-17-demethoxygeldanamycin-induced heat shock protein 90 inhibition in pancreatic cancer cells.Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.Macrocyclic inhibitors of hsp90 Heat shock protein-90 inhibitors enhance antigen expression on melanomas and increase T cell recognition of tumor cells Heat shock protein 90 inhibition in lung cancer.ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia.Anti-malarial activity of geldanamycin derivatives in mice infected with Plasmodium yoelii.Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.HSP90: a rising star on the horizon of anticancer targets.The non-Geldanamycin Hsp90 inhibitors enhanced the antifungal activity of fluconazole.Synthesis and evaluation of 11β-(4-substituted phenyl) estradiol analogs: transition from estrogen receptor agonists to antagonists.Enzyme specific activation of benzoquinone ansamycin prodrugs using HuCC49DeltaCH2-beta-galactosidase conjugates Active drug encapsulation and release kinetics from hydrogel-in-liposome nanoparticles Discovery and development of heat shock protein 90 inhibitors.A small molecule cell-impermeant Hsp90 antagonist inhibits tumor cell motility and invasion.Hsp90 as a gatekeeper of tumor angiogenesis: clinical promise and potential pitfalls.Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives.Natural Product Inspired N-Terminal Hsp90 Inhibitors: From Bench to Bedside?Mccrearamycins A-D, Geldanamycin-Derived Cyclopentenone Macrolactams from an Eastern Kentucky Abandoned Coal Mine Microbe.Evaluation of the radiosensitizing potency of chemotherapeutic agents in prostate cancer cells.Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte-derived macrophages.Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.Discovery of novel 17-phenylethylaminegeldanamycin derivatives as potent Hsp90 inhibitors.Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance Rapid engineering of the geldanamycin biosynthesis pathway by Red/ET recombination and gene complementation HSP90 affects the stability of BMAL1 and circadian gene expression.Biasing Potential Replica Exchange Multisite λ-Dynamics for Efficient Free Energy Calculations.Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.Pseudoverticin B, a novel geldanamycin analog obtained as new cell cycle inhibitor from Streptomyces pseudoverticillus YN17707.

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P2860

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

http://www.wikidata.org/entity/Q31115482

description

2004 nî lūn-bûn

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2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2004 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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name

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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label

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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prefLabel

Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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J.BMC.2004.07.053

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Bioorganic & Medicinal Chemistry

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Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.

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Christopher W Carreras

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Dan Zhang

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Daniel V Santi

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David C Myles

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Giulio Rastelli

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Steven D Dong

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Yaoquan Liu

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Yiqing Zhou

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Zhan Wang

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Zong-Qiang Tian

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5317-5329

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scholarly article

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10.1016/J.BMC.2004.07.053

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20

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12

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