Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design. - Wikidata - awgldk - TriplyDB

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

http://www.wikidata.org/entity/Q31115693

about

Identification of direct protein targets of small molecules Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes Applications of small molecule probes in dissecting mechanisms of bacterial virulence and host responses Chemical biology approaches for the study of apicomplexan parasites Development of calpain-specific inactivators by screening of positional scanning epoxide libraries Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference FINDSITE: a threading-based approach to ligand homology modeling Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 Localization of binding sites in protein structures by optimization of a composite scoring function Chemical proteomics from a nuclear magnetic resonance spectroscopy perspective.Proteomic profiling of metalloprotease activities with cocktails of active-site probes.Design of cell-permeable, fluorescent activity-based probes for the lysosomal cysteine protease asparaginyl endopeptidase (AEP)/legumain.Using specificity to strategically target proteases.Strategies for discovering and derisking covalent, irreversible enzyme inhibitors.Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics.Proteomic characterization of serine hydrolase activity and composition in normal urine.Assignment of protein function in the postgenomic era.Activity-based protein profiling for biochemical pathway discovery in cancer.Cathepsin L in secretory vesicles functions as a prohormone-processing enzyme for production of the enkephalin peptide neurotransmitter.Cysteine Cathepsins in the secretory vesicle produce active peptides: Cathepsin L generates peptide neurotransmitters and cathepsin B produces beta-amyloid of Alzheimer's disease Genomics and proteomics tools for compound mode-of-action studies in drug discovery.A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines.Exploring biology with small organic molecules.Apoplastic effectors secreted by two unrelated eukaryotic plant pathogens target the tomato defense protease Rcr3 Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.Activity-based probes as a tool for functional proteomic analysis of proteases.3D/4D functional imaging of tumor-associated proteolysis: impact of microenvironment.Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology.Activity based protein profiling to detect serine hydrolase alterations in virus infected cells Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.Chalcone: A Privileged Structure in Medicinal Chemistry.STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation.Mining the Active Proteome of Arabidopsis thaliana.Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.Global substrate specificity profiling of post-translational modifying enzymes.Solid-phase synthesis of double-headed epoxysuccinyl activity-based probes for selective targeting of papain family cysteine proteases.

P2860

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P2860

Small molecule affinity fingerprinting. A tool for enzyme family subclassification, target identification, and inhibitor design.

http://www.wikidata.org/entity/Q31115693

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年学术文章

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2002年学术文章

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2002年学术文章

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2002年学术文章

@zh-my

2002年学术文章

@zh-sg

2002年學術文章

@yue

name

Small molecule affinity finger ...... ication, and inhibitor design.

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Small molecule affinity finger ...... ication, and inhibitor design.

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type

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Small molecule affinity finger ...... ication, and inhibitor design.

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Small molecule affinity finger ...... ication, and inhibitor design.

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prefLabel

Small molecule affinity finger ...... ication, and inhibitor design.

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Small molecule affinity finger ...... ication, and inhibitor design.

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Chemistry and Biology

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Small molecule affinity finger ...... ication, and inhibitor design.

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Amos Baruch

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Dieter Brömme

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Doron C Greenbaum

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Felice Lu

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Irwin D Kuntz

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Jennifer Krumrine

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Kareem Chehade

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Linda Hayrapetian

http://www.w3.org/2001/XMLSchema#string

Samuel Toba

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William D Arnold

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1085-1094

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scholarly article

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10.1016/S1074-5521(02)00238-7

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10

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9

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2002-10-01T00:00:00Z

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12401493

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