Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2): loop 6 is a novel angiogenesis inhibitor.
about
Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cellsTemporal and spatial expression of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and -2) in the bovine corpus luteumTIMP-2 modulates cancer cell transcriptional profile and enhances E-cadherin/beta-catenin complex expression in A549 lung cancer cellsEquivalence of conventionally-derived and parthenote-derived human embryonic stem cellsPotential regulatory relationship between the nested gene DDC8 and its host gene tissue inhibitor of metalloproteinase-2Matrilin-1 is an inhibitor of neovascularization.The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversityMatrix metalloproteinase control of capillary morphogenesis.TIMP-2 modulates VEGFR-2 phosphorylation and enhances phosphodiesterase activity in endothelial cells.The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor.Tissue inhibitor of metalloproteinases-3 peptides inhibit angiogenesis and choroidal neovascularization in miceAn endogenous inhibitor of angiogenesis inversely correlates with side population phenotype and function in human lung cancer cells.Adult mouse epicardium modulates myocardial injury by secreting paracrine factors.An integrin-binding N-terminal peptide region of TIMP-2 retains potent angio-inhibitory and anti-tumorigenic activity in vivo.Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment.Tissue inhibitor of metalloproteinases-2 improves antitumor efficacy of a replicating adenovirus in vivo.Enhanced immunoreactivity of TIMP-2 in the stromal compartment of tumor as a marker of favorable prognosis in ovarian cancer patients.ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast CancerAn engineered TIMP2-based and enediyne-integrated fusion protein for targeting MMP-14 shows potent antitumor efficacy.Antagonism of VEGF-A-induced increase in vascular permeability by an integrin α3β1-Shp-1-cAMP/PKA pathway.Lipocalin 2 is a novel regulator of angiogenesis in human breast cancer.The endogenous zinc finger transcription factor, ZNF24, modulates the angiogenic potential of human microvascular endothelial cells.Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities.A systematic methodology for proteome-wide identification of peptides inhibiting the proliferation and migration of endothelial cells.TIMP-2 disrupts FGF-2-induced downstream signaling pathways.The tumor microenvironment: regulation by MMP-independent effects of tissue inhibitor of metalloproteinases-2.Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer.Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).TIMPs: versatile extracellular regulators in cancer.Differential TIMP3 expression affects tumor progression and angiogenesis in melanomas through regulation of directionally persistent endothelial cell migration.Regulation of TIMP-2, MT1-MMP, and MMP-2 expression during C2C12 differentiation.Inactivation of the tissue inhibitor of metalloproteinases-2 gene by promoter hypermethylation in lymphoid malignancies.A critical role for matrix metalloproteinases in liver regeneration.Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates neuromuscular junction development via a beta1 integrin-mediated mechanism.Extracellular matrix proteins and tumor angiogenesis.Tissue inhibitor of metalloproteinase-2 (TIMP-2) regulates myogenesis and beta1 integrin expression in vitro.Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution.Domain specific overexpression of TIMP-2 and TIMP-3 reveals MMP-independent functions of TIMPs during Xenopus laevis development.Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14.
P2860
Q24297942-FC90423D-C3E1-400D-80E6-73529E25A11CQ24796638-9C619762-F8FC-4693-9182-153FB1B4CF3FQ28385210-66F0C2D8-9EFA-43EC-9ECF-E76924FF671AQ28743631-C43E27A4-591A-48ED-B2F4-1A4EAA39DEAAQ30561811-0B197002-9E5C-41FE-AF7D-55E3DD9FB4F2Q33619544-357F9C78-C8AA-498C-BC44-098560C064F5Q33786342-E1ED60FA-F1E5-44F3-94D3-407F117DCAC3Q34002149-1E72DECC-9E14-4FA3-861A-B3354708174CQ34018800-2B0E95E3-ED85-456E-AACD-59C0F57D97D5Q34439011-5DDAAC03-99BE-464F-8572-AE5BDE435063Q34612933-FF29079F-C882-4812-851A-B3848D13DFA4Q34615538-002F4D30-EF91-4DB6-AF22-33FE57D3F6AEQ34875955-0118F817-845D-4120-9CF4-8A538F5758CEQ35224732-3273E4F7-4702-4376-8D42-CF2200106405Q35475215-E8A527CA-C6D4-4DF5-B7EA-6B918010300EQ35633833-342B881C-ED86-45CA-B494-04BF8EA768A5Q36285869-153A6501-39B4-4592-AC07-5E6E6CA824FDQ36372319-C90D217F-EA1E-403B-BD7F-ED36FC8887C5Q36413450-AE5E08DB-EFE4-479F-9DF0-4BC3010E6C62Q36462433-39F83EAE-0ED4-490A-8766-33B4A5CEBB03Q36482942-165BBDA6-92A1-421D-AAD9-A86E6164104FQ36525804-97F5EAC2-F04D-418B-BB47-D0DB31C28389Q36805538-5C8EC677-E89B-408A-83FD-DC4EB7D93A4BQ36893507-0334ADB3-68C8-4006-AD04-0AA536A0E761Q36953427-2B8DE99E-FB8B-4858-BCC1-78F88C04F086Q37023899-33C459E8-5F64-4B90-A1D9-31440B3D255DQ37412311-29D7B24D-6772-4C08-994A-7B39D348D9D6Q38679451-EEC1A55C-28D8-4C73-847A-44B6A5D9A997Q38785433-EB42698B-26E0-46CD-9786-DA5F23573FB1Q39063857-B6259058-559B-426D-8CB6-7DAF88F275D0Q40400276-F41D2383-40AB-4EE5-8AAA-4954BF227966Q40426926-1DA32624-3A82-455A-9896-D6C03B798F25Q42262419-157BC9D6-FCB7-4054-A566-60B06F850407Q42361671-C48C564E-8805-451F-A33A-9118D248D10AQ42699734-272AE492-5685-422C-B6BD-E1056670101DQ42949077-5C1C7BB8-0401-4209-9DE2-E9AE24465ED4Q51044896-B9EB6987-D18D-4396-BA3C-037F88985A30Q51784855-A9530FEF-72A9-478F-9347-D84CAA3A04E2Q52688539-AB74D6B3-BD44-486E-97D2-98441F45FBF5
P2860
Structural and functional uncoupling of the enzymatic and angiogenic inhibitory activities of tissue inhibitor of metalloproteinase-2 (TIMP-2): loop 6 is a novel angiogenesis inhibitor.
description
2003 nî lūn-bûn
@nan
2003 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structural and functional unco ...... novel angiogenesis inhibitor.
@ast
Structural and functional unco ...... novel angiogenesis inhibitor.
@en
type
label
Structural and functional unco ...... novel angiogenesis inhibitor.
@ast
Structural and functional unco ...... novel angiogenesis inhibitor.
@en
prefLabel
Structural and functional unco ...... novel angiogenesis inhibitor.
@ast
Structural and functional unco ...... novel angiogenesis inhibitor.
@en
P2093
P356
P1476
Structural and functional unco ...... novel angiogenesis inhibitor.
@en
P2093
Catherine Butterfield
Cecilia A Fernández
Geraldine Jackson
Marsha A Moses
P304
40989-40995
P356
10.1074/JBC.M306176200
P407
P577
2003-08-04T00:00:00Z