Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition.
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Click chemistry in peptide-based drug designGetting in shape: controlling peptide bioactivity and bioavailability using conformational constraintsOxime side-chain cross-links in an α-helical coiled-coil protein: structure, thermodynamics, and folding-templated synthesis of bicyclic speciesConstraining cyclic peptides to mimic protein structure motifs.Solvent independent conformational propensities of [1,2,3]triazolyl-bridged parathyroid hormone-related peptide-derived cyclo-nonapeptide analogues.Comparative α-helicity of cyclic pentapeptides in water.Achieving cell penetration with distance-matching cysteine cross-linkers: a facile route to cell-permeable peptide dual inhibitors of Mdm2/Mdmx.Synthesis of chemically modified bioactive peptides: recent advances, challenges and developments for medicinal chemistry.Helical content of a β(3)-octapeptide in methanol: molecular dynamics simulations explain a seeming discrepancy between conclusions derived from CD and NMR data.Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.1,4-disubstituted-[1,2,3]triazolyl-containing analogues of MT-II: design, synthesis, conformational analysis, and biological activity.A readily applicable strategy to convert peptides to peptoid-based therapeutics.Photoinducible bioorthogonal chemistry: a spatiotemporally controllable tool to visualize and perturb proteins in live cells.5-aminomethyloxazolidine-2,4-dione hybrid α/β-dipeptide scaffolds as inductors of constrained conformations: Applications to the synthesis of integrin antagonists.Design of triazole-stapled BCL9 α-helical peptides to target the β-catenin/B-cell CLL/lymphoma 9 (BCL9) protein-protein interaction.Impact of the amino acid sequence on the conformation of side chain lactam-bridged octapeptides.Conjugation of spermine enhances cellular uptake of the stapled peptide-based inhibitors of p53-Mdm2 interactionPeptides and proteins as a continuing exciting source of inspiration for peptidomimetics.Click to join peptides/proteins together.Stabilized helical peptides: overview of the technologies and therapeutic promises.New modalities in conformationally constrained peptides for potency, selectivity and cell permeation.Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway.Modulating protein-protein interactions: the potential of peptides.An enhanced functional interrogation/manipulation of intracellular signaling pathways with the peptide 'stapling' technology.Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes.Design and synthesis of anti-cancer cyclopeptides containing triazole skeleton.Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction.Positional effects of click cyclization on β-hairpin structure, stability, and function.Intramolecular cyclization of the antimicrobial peptide Polybia-MPI with triazole stapling: influence on stability and bioactivity.Tuning the properties of a novel short cell-penetrating peptide by intramolecular cyclization with a triazole bridge.Helix induction by dirhodium: access to biocompatible metallopeptides with defined secondary structure.A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/β-catenin signalling pathway.Asymmetric synthesis of amines using tert-butanesulfinamide.Promoting peptide α-helix formation with dynamic covalent oxime side-chain cross-links.β-Amino acids containing peptides and click-cyclized peptide as β-turn mimics: a comparative study with 'conventional' lactam- and disulfide-bridged hexapeptides.Thermodynamic origin of α-helix stabilization by side-chain cross-links in a small protein.Diversity-Oriented Peptide Stapling: A Third Generation Copper-Catalysed Azide-Alkyne Cycloaddition Stapling and Functionalisation Strategy.A precisely positioned chiral center in an i, i + 7 tether modulates the helicity of the backbone peptide.An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide.Diaminodiacid-based solid-phase synthesis of all-hydrocarbon stapled α-helical peptides.
P2860
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P2860
Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition.
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
name
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@ast
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@en
type
label
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@ast
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@en
prefLabel
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@ast
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@en
P2093
P356
P1476
Synthesis and conformational a ...... yne 1,3-dipolar cycloaddition.
@en
P2093
Alexandra Le Chevalier Isaad
Anna Maria D'Ursi
Anna Maria Papini
Jay J Levy
Jose A Halperin
Mario Scrima
Michael Chorev
Paolo Rovero
Richard D DiMarchi
Sonia Cantel
P304
P356
10.1021/JO800142S
P407
P577
2008-05-20T00:00:00Z