Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
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From hepatoprotection models to new therapeutic modalities for treating liver diseases: a personal perspectiveNuclear Receptors as Therapeutic Targets in Liver Disease: Are We There Yet?Analysis of the heat shock response in mouse liver reveals transcriptional dependence on the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors.Regulation of Proteome Maintenance Gene Expression by Activators of Peroxisome Proliferator-Activated Receptor α.Evaluation of alpha-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity.Key issues in the role of peroxisome proliferator-activated receptor agonism and cell signaling in trichloroethylene toxicity.Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver.Differential gene expression in mouse liver associated with the hepatoprotective effect of clofibratePeroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity.The toxicology of ligands for peroxisome proliferator-activated receptors (PPAR).Targeted Metabolomics of Serum Acylcarnitines Evaluates Hepatoprotective Effect of Wuzhi Tablet (Schisandra sphenanthera Extract) against Acute Acetaminophen Toxicity.Enhanced hepatotoxicity by acetaminophen in Vanin-1 knockout mice is associated with deficient proliferative and immune responses.Clofibrate-induced changes in the liver, heart, brain and white adipose lipid metabolome of Swiss-Webster miceMetabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis.Serum metabolomics reveals irreversible inhibition of fatty acid beta-oxidation through the suppression of PPARalpha activation as a contributing mechanism of acetaminophen-induced hepatotoxicity.Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicityAcylcarnitine profiles in acetaminophen toxicity in the mouse: comparison to toxicity, metabolism and hepatocyte regeneration.Analysis of changes in hepatic gene expression in a murine model of tolerance to acetaminophen hepatotoxicity (autoprotection).Final report of the safety assessment of cosmetic ingredients derived from Zea mays (corn).Kupffer cells suppress perfluorononanoic acid-induced hepatic peroxisome proliferator-activated receptor α expression by releasing cytokines.Hepatic transcriptome and proteome responses against diethyl maleate-induced glutathione depletion in the rat.The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes.Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.The PPARα-dependent rodent liver tumor response is not relevant to humans: addressing misconceptions.Biochemical targets of drugs mitigating oxidative stress via redox-independent mechanisms.Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse.Decreased longevity and enhancement of age-dependent lesions in mice lacking the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha).Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions.
P2860
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P2860
Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.
description
2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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name
Peroxisome proliferator-activa ...... following clofibrate exposure.
@ast
Peroxisome proliferator-activa ...... following clofibrate exposure.
@en
type
label
Peroxisome proliferator-activa ...... following clofibrate exposure.
@ast
Peroxisome proliferator-activa ...... following clofibrate exposure.
@en
prefLabel
Peroxisome proliferator-activa ...... following clofibrate exposure.
@ast
Peroxisome proliferator-activa ...... following clofibrate exposure.
@en
P2093
P356
P1476
Peroxisome proliferator-activa ...... following clofibrate exposure.
@en
P2093
G E Hennig
H E Whiteley
J C Corton
J E Manautou
P304
P356
10.1093/TOXSCI/57.2.338
P577
2000-10-01T00:00:00Z