Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. - Wikidata - awgldk - TriplyDB

Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.

Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.

http://www.wikidata.org/entity/Q46068587

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Acetaminophen-induced Liver Injury: from Animal Models to Humans Idiosyncratic adverse drug reactions: current concepts Mechanisms of drug-induced liver injury Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications Acetaminophen reactive intermediates target hepatic thioredoxin reductase Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity Mechanisms of acetaminophen hepatotoxicity and their translation to the human pathophysiology.Mechanisms of immune-mediated liver injury.Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.Acetaminophen-induced hepatotoxicity in mice occurs with inhibition of activity and nitration of mitochondrial manganese superoxide dismutase Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.Hepatitis C virus structural proteins can exacerbate or ameliorate acetaminophen-induced liver injury in mice.Acetaminophen-induced hepatotoxicity and protein nitration in neuronal nitric-oxide synthase knockout mice Plasma and liver acetaminophen-protein adduct levels in mice after acetaminophen treatment: dose-response, mechanisms, and clinical implications.Mechanism of protection by metallothionein against acetaminophen hepatotoxicity.Drug-induced liver injury: insights from genetic studies.Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity Bacterial β-glucuronidase inhibition protects mice against enteropathy induced by indomethacin, ketoprofen or diclofenac: mode of action and pharmacokinetics Animal models of idiosyncratic drug-induced liver injury--current status.Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria.Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity.Mechanistic biomarkers in acetaminophen-induced hepatotoxicity and acute liver failure: from preclinical models to patients.Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.Acetaminophen (APAP) hepatotoxicity-Isn't it time for APAP to go away?Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.Serum markers for mitochondrial dysfunction and cell death are possible predictive indicators for drug-induced liver injury by direct acting antivirals.Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury.Fast food diet-induced non-alcoholic fatty liver disease exerts early protective effect against acetaminophen intoxication in mice.In vitro to in vivo extrapolation and species response comparisons for drug-induced liver injury (DILI) using DILIsym™: a mechanistic, mathematical model of DILI.Acetaminophen Toxicity Novel Insights into Mechanisms and Future Perspectives.EXTRAHEPATIC TOXICITY OF ACETAMINOPHEN: CRITICAL EVALUATION OF THE EVIDENCE AND PROPOSED MECHANISMS.Prediction of hepatotoxicity for drugs using human pluripotent stem cell-derived hepatocytes.Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.

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Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.

http://www.wikidata.org/entity/Q46068587

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2009 nî lūn-bûn

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2009年の論文

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2009年学术文章

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2009年学术文章

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2009年学术文章

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2009年學術文章

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Sensitivity of liver injury in ...... troglitazone or acetaminophen.

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Toxicologic Pathology

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Sensitivity of liver injury in ...... troglitazone or acetaminophen.

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Kazumi Ito

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Kazunori Fujimoto

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Kazuyoshi Kumagai

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Sen-ichi Oda

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Shingo Arakawa

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Sunao Manabe

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Takashi Yamoto

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Yosuke Ando

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P2860

Acetaminophen-induced hepatotoxicity

Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice

Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.

Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

The significance of mitochondrial toxicity testing in drug development.

Diabetic KKAy mice exhibit increased hepatic PPARgamma1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones.

Troglitazone induces a rapid drop of mitochondrial membrane potential in liver HepG2 cells.

Effects of troglitazone on HepG2 viability and mitochondrial function.

Involvement of mitochondrial permeability transition in acetaminophen-induced liver injury in mice.

Rodent carcinogenicity with the thiazolidinedione antidiabetic agent troglitazone.

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