Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
about
Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophoreStructure-guided development of selective RabGGTase inhibitorsThematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylationMeasurement of protein farnesylation and geranylgeranylation in vitro, in cultured cells and in biopsies, and the effects of prenyl transferase inhibitorsTargeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome.Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agentsLipid posttranslational modifications. Farnesyl transferase inhibitors.Combination therapy with imatinib mesylate (STI571): synopsis of in vitro studies.Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia.JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis.Copper-promoted synthesis of 1,4-benzodiazepinones via alkene diamination.Emerging treatments in acute myeloid leukaemia.Group IVC cytosolic phospholipase A2gamma is farnesylated and palmitoylated in mammalian cells.Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasitesCurrent status of agents active against the T315I chronic myeloid leukemia phenotype.New therapeutic approaches to acute myeloid leukemia.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status.Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials.Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines.Synthesis of saturated 1,4-benzodiazepines via Pd-catalyzed carboamination reactions.Design, synthesis and anti-tobacco mosaic virus (TMV) activity of 5-chloro-N-(4-cyano-1-aryl-1H-pyrazol-5-yl)-1-aryl-3-methyl-1H-pyrazole-4-carboxamide derivatives.Design, Synthesis and Evaluation of Novel 1-(Substituted Acetyl)-4-(10-Bromo-8-Chloro-5,6-Dihydro-11H-Benzo[5,6]Cyclohepta[1,2-B]Pyridine-11-Ylidene)piperidines as Antitumor Agents and Farnesyl Protein Transferase Inhibitors.Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies.Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter.An aqueous fluorescent probe for Hg(2+) detection with high selectivity and sensitivity.Syntheses of Tetrahydrobenzodiazepines via SN2-Type Ring-Opening of Activated Aziridines with 2-Bromobenzylamine Followed by Copper-Powder-Mediated C−N Bond FormationSynthesis of Thieno[3,2-e][1,4]diazepin-2-ones: Application of an Uncatalysed Pictet-Spengler Reaction
P2860
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P2860
Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.
description
2000 nî lūn-bûn
@nan
2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@ast
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@en
type
label
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@ast
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@en
prefLabel
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@ast
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@en
P2093
P356
P1476
Discovery of (R)-7-cyano-2,3,4 ...... reclinical antitumor activity.
@en
P2093
Batorsky R
Gullo-Brown J
P304
P356
10.1021/JM000248Z
P407
P577
2000-10-01T00:00:00Z