Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation - Wikidata - awgldk - TriplyDB

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

http://www.wikidata.org/entity/Q28285888

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Resistance mutations at the lipid substrate binding site of Plasmodium falciparum protein farnesyltransferase Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase Structural Basis for Binding and Selectivity of Antimalarial and Anticancer Ethylenediamine Inhibitors to Protein Farnesyltransferase Structures of Cryptococcus neoformans Protein Farnesyltransferase Reveal Strategies for Developing Inhibitors That Target Fungal Pathogens Crystal structures of the fungal pathogenAspergillus fumigatusprotein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design Prenylation of Saccharomyces cerevisiae Chs4p Affects Chitin Synthase III activity and chitin chain length All about that fat: Lipid modification of proteins in Cryptococcus neoformans Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites Global proteomic analysis of prenylated proteins in Plasmodium falciparum using an alkyne-modified isoprenoid analogue Drug screening on Hutchinson Gilford progeria pluripotent stem cells reveals aminopyrimidines as new modulators of farnesylation.Cluster analysis of Plasmodium RNA-seq time-course data identifies stage-specific co-regulated biological processes and regulatory elements.Protein post-translational modifications: In silico prediction tools and molecular modeling.Targeting protein prenylation for cancer therapy Prediction and evaluation of protein farnesyltransferase inhibition by commercial drugs.Therapeutic intervention based on protein prenylation and associated modifications Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design.Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease.Mislocalization of prelamin A Tyr646Phe mutant to the nuclear pore complex in human embryonic kidney 293 cells.Protein palmitoylation and pathogenesis in apicomplexan parasites.2-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials Kinetoplastids: related protozoan pathogens, different diseases.Lipidomics of host-pathogen interactions.Adaptations in the lipid metabolism of the protozoan parasite Trypanosoma brucei.Lipid metabolism in Trypanosoma brucei Recent highlights in antimalarial drug resistance and chemotherapy research.Restricted substrate specificity for the geranylgeranyltransferase-I enzyme in Cryptococcus neoformans: implications for virulence.Target-based drug discovery for human African trypanosomiasis: selection of molecular target and chemical matter.Heterologous expression studies of Saccharomyces cerevisiae reveal two distinct trypanosomatid CaaX protease activities and identify their potential targets.State of the art in African trypanosome drug discovery.Development of novel drugs for human African trypanosomiasis.Exploring protein lipidation with chemical biology.Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections.Exploring the biochemistry of the prenylome and its role in disease through proteomics: progress and potential.Alkynyl-farnesol reporters for detection of protein S-prenylation in cells.Synthesis of imidazole-containing analogues of farnesyl pyrophosphate and evaluation of their biological activity on protein farnesyltransferase.Ras Isoprenylation and pAkt Inhibition by Zoledronic Acid and Fluvastatin Enhances Paclitaxel Activity in T24 Bladder Cancer Cells.New antiplasmodial bromotyrosine derivatives from Suberea ianthelliformis Lendenfeld, 1888.Three-dimensional quantitative structure-farnesyltransferase inhibition analysis for some diaminobenzophenones.

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Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

http://www.wikidata.org/entity/Q28285888

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Thematic review series: lipid ...... blocking protein farnesylation

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Thematic review series: lipid ...... blocking protein farnesylation

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Thematic review series: lipid ...... blocking protein farnesylation

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Thematic review series: lipid ...... blocking protein farnesylation

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Thematic review series: lipid ...... blocking protein farnesylation

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Thematic review series: lipid ...... blocking protein farnesylation

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P1433

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JLR.R500016-JLR200

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Journal of Lipid Research

P1476

Thematic review series: lipid ...... blocking protein farnesylation

@en

P2093

Frederick S Buckner

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Kohei Yokoyama

http://www.w3.org/2001/XMLSchema#string

Richard T Eastman

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P2860

Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

The CaaX proteases, Afc1p and Rce1p, have overlapping but distinct substrate specificities.

Protein farnesyltransferase and protein prenylation in Plasmodium falciparum

Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs

TcRho1, a farnesylated Rho family homologue from Trypanosoma cruzi: cloning, trans-splicing, and prenylation studies.

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.

Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.

Phase II study of the farnesyl transferase inhibitor R115777 in patients with sensitive relapse small-cell lung cancer.

Phase III double-blind placebo-controlled study of farnesyl transferase inhibitor R115777 in patients with refractory advanced colorectal cancer.

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

P304

233-40

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scholarly article

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4194837

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10.1194/JLR.R500016-JLR200

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P407

P433

2

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47

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P50

Wesley C Van Voorhis

Michael H. Gelb

P577

2006-02-01T00:00:00Z

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P698

16339110

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