Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
about
Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channelsThe epithelial anion transporter pendrin is induced by allergy and rhinovirus infection, regulates airway surface liquid, and increases airway reactivity and inflammation in an asthma modelRole of S3 and S4 transmembrane domain charged amino acids in channel biogenesis and gating of KCa2.3 and KCa3.1Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observedMucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colonInvestigating CFTR and KCa3.1 Protein/Protein InteractionsNaphtho[1,2-d]thiazol-2-ylamine (SKA-31), a new activator of KCa2 and KCa3.1 potassium channels, potentiates the endothelium-derived hyperpolarizing factor response and lowers blood pressureMolecular and cellular basis of small--and intermediate-conductance, calcium-activated potassium channel function in the brain.Cystic fibrosis: exploiting its genetic basis in the hunt for new therapiesRecycling of the Ca2+-activated K+ channel, KCa2.3, is dependent upon RME-1, Rab35/EPI64C, and an N-terminal domainThe K+ channel opener 1-EBIO potentiates residual function of mutant CFTR in rectal biopsies from cystic fibrosis patients.Cloning and identification of tissue-specific expression of KCNN4 splice variants in rat colon.The activation effect of hainantoxin-I, a peptide toxin from the Chinese spider, Ornithoctonus hainana, on intermediate-conductance Ca2+-activated K+ channels.New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1.ESCRT-dependent targeting of plasma membrane localized KCa3.1 to the lysosomesAnterograde trafficking of KCa3.1 in polarized epithelia is Rab1- and Rab8-dependent and recycling endosome-independentTargeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin InterfaceMechanistic details of BK channel inhibition by the intermediate conductance, Ca2+-activated K channel.Synthesis and antibacterial activities of 1-alkyl-3-methacryloyl (acryloyl) of benzimidazolone (thione) derivatives.Therapeutic potential of KCa3.1 blockers: recent advances and promising trends.An NH2-terminal multi-basic RKR motif is required for the ATP-dependent regulation of hIK1.Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts?Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel.Protection against cardiac injury by small Ca(2+)-sensitive K(+) channels identified in guinea pig cardiac inner mitochondrial membraneCysteine mutagenesis and computer modeling of the S6 region of an intermediate conductance IKCa channel.Vascular KCa-channels as therapeutic targets in hypertension and restenosis disease.Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilationThe role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels.K+ channel modulators for the treatment of neurological disorders and autoimmune diseasesEndothelial Ca+-activated K+ channels in normal and impaired EDHF-dilator responses--relevance to cardiovascular pathologies and drug discoveryEnhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.Evidence of K+ channel function in epithelial cell migration, proliferation, and repair.Aromatic-aromatic interactions between residues in KCa3.1 pore helix and S5 transmembrane segment control the channel gating process.Molecular basis of potassium channels in pancreatic duct epithelial cellsModulation of Retrograde Trafficking of KCa3.1 in a Polarized EpitheliumBenzimidazolones enhance the function of epithelial Na⁺ transport.Ca2+-activated K channels in parotid acinar cells: The functional basis for the hyperpolarized activation of BK channels.Chloride transporting capability of Calu-3 epithelia following persistent knockdown of the cystic fibrosis transmembrane conductance regulator, CFTR.Expression of intermediate-conductance, Ca2+-activated K+ channel (KCNN4) in H441 human distal airway epithelial cells.4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells
P2860
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P2860
Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease.
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Benzimidazolone activators of ...... obstructive pulmonary disease.
@ast
Benzimidazolone activators of ...... obstructive pulmonary disease.
@en
type
label
Benzimidazolone activators of ...... obstructive pulmonary disease.
@ast
Benzimidazolone activators of ...... obstructive pulmonary disease.
@en
prefLabel
Benzimidazolone activators of ...... obstructive pulmonary disease.
@ast
Benzimidazolone activators of ...... obstructive pulmonary disease.
@en
P2093
P1476
Benzimidazolone activators of ...... obstructive pulmonary disease
@en
P2093
P304
P407
P577
2001-02-01T00:00:00Z