Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A.
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Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor DesignPredicting Allosteric Effects from Orthosteric Binding in Hsp90-Ligand Interactions: Implications for Fragment-Based Drug DesigncAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMPRapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry.Identification of the protein kinase A regulatory RIalpha-catalytic subunit interface by amide H/2H exchange and protein docking.Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and dockingAutomated extraction of backbone deuteration levels from amide H/2H mass spectrometry experiments.A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.Troponin regulatory function and dynamics revealed by H/D exchange-mass spectrometry.Amide hydrogen/deuterium exchange & MALDI-TOF mass spectrometry analysis of Pak2 activation.Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by SDSL and EPR.Active site coupling in PDE:PKA complexes promotes resetting of mammalian cAMP signaling.Cyclic AMP- and (Rp)-cAMPS-induced conformational changes in a complex of the catalytic and regulatory (RI{alpha}) subunits of cyclic AMP-dependent protein kinase.Phosphodiesterases catalyze hydrolysis of cAMP-bound to regulatory subunit of protein kinase A and mediate signal termination.cAMP activation of PKA defines an ancient signaling mechanism.Cyclic AMP-induced conformational changes in mycobacterial protein acetyltransferases.Parallel Allostery by cAMP and PDE Coordinates Activation and Termination Phases in cAMP Signaling.R-subunit isoform specificity in protein kinase A: distinct features of protein interfaces in PKA types I and II by amide H/2H exchange mass spectrometry.Dissecting interdomain communication within cAPK regulatory subunit type IIbeta using enhanced amide hydrogen/deuterium exchange mass spectrometry (DXMS)Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.Unraveling the dynamics of protein interactions with quantitative mass spectrometry.Regio-Selective Intramolecular Hydrogen/Deuterium Exchange in Gas-Phase Electron Transfer Dissociation.Determination of Equine Cytochrome c Backbone Amide Hydrogen/Deuterium Exchange Rates by Mass Spectrometry Using a Wider Time Window and Isotope Envelope.Conformational changes in oxidatively stressed monoclonal antibodies studied by hydrogen exchange mass spectrometryDetection of native-state nonadditivity in double mutant cycles via hydrogen exchange.Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange.Molecular Simulations Reveal an Unresolved Conformation of the Type IA Protein Kinase A Regulatory Subunit and Suggest Its Role in the cAMP Regulatory Mechanism.Application of amide proton exchange mass spectrometry for the study of protein-protein interactions.Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins.Hydrogen-deuterium exchange reveals long-range dynamical allostery in soybean lipoxygenase.A model for agonism and antagonism in an ancient and ubiquitous cAMP-binding domain.C subunits binding to the protein kinase A RI alpha dimer induce a large conformational change.Rearrangements in a hydrophobic core region mediate cAMP action in the regulatory subunit of PKA
P2860
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P2860
Amide H/2H exchange reveals communication between the cAMP and catalytic subunit-binding sites in the R(I)alpha subunit of protein kinase A.
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@ast
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@en
type
label
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@ast
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@en
prefLabel
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@ast
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@en
P2093
P1476
Amide H/2H exchange reveals co ...... a subunit of protein kinase A.
@en
P2093
Carrie A Hughes
Elizabeth A Komives
Ganesh S Anand
John M Jones
Susan S Taylor
P304
P356
10.1016/S0022-2836(02)00919-1
P407
P577
2002-10-01T00:00:00Z