Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration. - Wikidata - awgldk - TriplyDB

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

http://www.wikidata.org/entity/Q33195171

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Inhibition of calpain prevents NMDA-induced cell death and beta-amyloid-induced synaptic dysfunction in hippocampal slice cultures Post-translational generation of constitutively active cores from larger phosphatases in the malaria parasite, Plasmodium falciparum: implications for proteomics Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain Phospholipase Cdelta1 associates with importin beta1 and translocates into the nucleus in a Ca2+-dependent manner Calpain activation is required for glutamate-induced p27 down-regulation in cultured cortical neurons Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease Membrane depolarization inhibits spiral ganglion neurite growth via activation of multiple types of voltage sensitive calcium channels and calpain Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.Calpain activation in experimental glaucoma.Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation.Postsynaptic density-95 (PSD-95) and calcineurin control the sensitivity of N-methyl-D-aspartate receptors to calpain cleavage in cortical neurons.RNAi targeting micro-calpain increases neuron survival and preserves hippocampal function after global brain ischemia.Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma A functional interplay between 5-lipoxygenase and μ-calpain affects survival and cytokine profile of human Jurkat T lymphocyte exposed to simulated microgravity Parkin regulates kainate receptors by interacting with the GluK2 subunit Proteolysis of calcineurin is increased in human hippocampus during mild cognitive impairment and is stimulated by oligomeric Abeta in primary cell culture.Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease.Synaptic therapy in Alzheimer's disease: a CREB-centric approach.Postinjury estrogen treatment of chronic spinal cord injury improves locomotor function in rats Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.The role of calcineurin signaling in microcystin-LR triggered neuronal toxicity.Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE.Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease.Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.Calpain-Mediated Cleavage of Calcineurin in Puromycin Aminonucleoside-Induced Podocyte Injury.Activation of protein phosphatase 2B and hyperphosphorylation of Tau in Alzheimer's disease.In vitro stretch injury induces time- and severity-dependent alterations of STEP phosphorylation and proteolysis in neurons.Regulation and physiological roles of the calpain system in muscular disorders Calcineurin activation causes retinal ganglion cell degeneration.Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertension.IL-1RAcPb signaling regulates adaptive mechanisms in neurons that promote their long-term survival following excitotoxic insults.Cooperative autoinhibition and multi-level activation mechanisms of calcineurin Non-conventional apoptotic response to ionising radiation mediated by N-methyl D-aspartate receptors in immature neuronal cells.A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity Mechanistic role of calpains in postischemic neurodegeneration.Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats.Knockdown of m-calpain increases survival of primary hippocampal neurons following NMDA excitotoxicity.Estrogen attenuates glutamate-induced cell death by inhibiting Ca2+ influx through L-type voltage-gated Ca2+ channels.Novel Ser/Thr protein phosphatases in cell death regulation

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P2860

Critical role of calpain-mediated cleavage of calcineurin in excitotoxic neurodegeneration.

http://www.wikidata.org/entity/Q33195171

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2003 nî lūn-bûn

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2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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Critical role of calpain-media ...... excitotoxic neurodegeneration.

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Critical role of calpain-media ...... excitotoxic neurodegeneration.

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Critical role of calpain-media ...... excitotoxic neurodegeneration.

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Critical role of calpain-media ...... excitotoxic neurodegeneration.

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Critical role of calpain-media ...... excitotoxic neurodegeneration.

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Critical role of calpain-media ...... excitotoxic neurodegeneration.

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Journal of Biological Chemistry

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Critical role of calpain-media ...... excitotoxic neurodegeneration

@en

P2093

Akiyoshi Moriwaki

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Fan-Yan Wei

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Hai-Yan Wu

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Hideki Matsui

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Kazuhito Tomizawa

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Masayuki Matsushita

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Yoshiya Oda

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Yun-Fei Lu

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P2860

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

Neurotoxicity induces cleavage of p35 to p25 by calpain

Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2

Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy

Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death.

Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice

Calpain and caspase: can you tell the difference?

Brain ischemia and reperfusion: molecular mechanisms of neuronal injury.

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6

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279

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14627704

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