Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.
about
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genesCullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resectionInactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis by haploid insufficiencyCtp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombinationContribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4.Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation.Tetrameric Ctp1 coordinates DNA binding and DNA bridging in DNA double-strand-break repair.Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein.Two separable functions of Ctp1 in the early steps of meiotic DNA double-strand break repairCtIP protein dimerization is critical for its recruitment to chromosomal DNA double-stranded breaks.A conserved function for a Caenorhabditis elegans Com1/Sae2/CtIP protein homolog in meiotic recombination.Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex.DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints.Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection.Structural studies of DNA end detection and resection in homologous recombination.CtIP/Ctp1/Sae2, molecular form fit for function.CtIP links DNA double-strand break sensing to resection.CtIP tetramer assembly is required for DNA-end resection and repair.When two is not enough: a CtIP tetramer is required for DNA repair by Homologous Recombination.CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression.
P2860
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P2860
Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif.
description
2004 nî lūn-bûn
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2004 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2004 թվականի ապրիլին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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name
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@ast
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@en
type
label
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@ast
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@en
prefLabel
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@ast
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@en
P2093
P2860
P50
P356
P1476
Dimerization of CtIP, a BRCA1- ...... N-terminal coiled-coil motif.
@en
P2093
Eleanor Y M Sum
J N Mark Glover
Jane E Visvader
Philippa H Stokes
R Scott Williams
Valentina A Valova
P2860
P304
26932-26938
P356
10.1074/JBC.M313974200
P407
P577
2004-04-14T00:00:00Z