Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.
about
DENV inhibits type I IFN production in infected cells by cleaving human STINGMolecular targets for flavivirus drug discoveryDevelopment and utility of an in vitro, fluorescence-based assay for the discovery of novel compounds against dengue 2 viral proteaseMechanisms of activation and inhibition of Zika virus NS2B-NS3 proteaseCleavage targets and the D-arginine-based inhibitors of the West Nile virus NS3 processing proteinaseProbing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptidesCleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile virusesSwitching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based MutagenesisStructural evidence for regulation and specificity of flaviviral proteases and evolution of theFlaviviridaefoldCrystal Structure of the NS3 Protease-Helicase from Dengue VirusFunctional Analysis of Potential Carboxy-Terminal Cleavage Sites of Tick-Borne Encephalitis Virus Capsid ProteinMechanism of NS2B-Mediated Activation of NS3pro in Dengue Virus: Molecular Dynamics Simulations and BioassaysLigand-Bound Structures of the Dengue Virus Protease Reveal the Active ConformationStructure of the NS2B-NS3 protease from Zika virus after self-cleavageHigh affinity human antibody fragments to dengue virus non-structural protein 3Probing of exosites leads to novel inhibitor scaffolds of HCV NS3/4A proteinaseEnzymatic analysis of recombinant Japanese encephalitis virus NS2B(H)-NS3pro protease with fluorogenic model peptide substratesBroad-spectrum agents for flaviviral infections: dengue, Zika and beyondDengue Virus Non-Structural Protein 5Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists.Transplantation of a hydrogen bonding network from West Nile virus protease onto Dengue-2 protease improves catalytic efficiency and sheds light on substrate specificity.Designing cyclic peptide inhibitor of dengue virus NS3-NS2B protease by using molecular docking approach.Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus.Solution conformations of Zika NS2B-NS3pro and its inhibition by natural products from edible plantsSubstrate specifity profiling of the Aspergillus fumigatus proteolytic secretome reveals consensus motifs with predominance of Ile/Leu and Phe/TyrUse of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors.Inhibition of Dengue virus and West Nile virus proteases by click chemistry-derived benz[d]isothiazol-3(2H)-one derivatives.C-terminal residue optimization and fragment merging: discovery of a potent Peptide-hybrid inhibitor of dengue protease.Emerging principles in protease-based drug discovery.Anthracene-based inhibitors of dengue virus NS2B-NS3 proteaseThe flavivirus protease as a target for drug discovery.Small molecule pan-dengue and West Nile virus NS3 protease inhibitors.The C-terminal 50 amino acid residues of dengue NS3 protein are important for NS3-NS5 interaction and viral replicationA small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture.Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus.Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells.Identification of covalent active site inhibitors of dengue virus protease.Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease.Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity.Context-Dependent Cleavage of the Capsid Protein by the West Nile Virus Protease Modulates the Efficiency of Virus Assembly
P2860
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P2860
Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Functional profiling of recomb ...... tapeptide substrate libraries.
@ast
Functional profiling of recomb ...... tapeptide substrate libraries.
@en
type
label
Functional profiling of recomb ...... tapeptide substrate libraries.
@ast
Functional profiling of recomb ...... tapeptide substrate libraries.
@en
prefLabel
Functional profiling of recomb ...... tapeptide substrate libraries.
@ast
Functional profiling of recomb ...... tapeptide substrate libraries.
@en
P2093
P2860
P356
P1476
Functional profiling of recomb ...... ctapeptide substrate libraries
@en
P2093
Christine Tumanut
David Beer
David C Tully
Daying Wen
Jan Jiricek
Jennifer A Williams
Jennifer L Harris
John P Priestle
Subhash G Vasudevan
P2860
P304
28766-28774
P356
10.1074/JBC.M500588200
P407
P577
2005-06-01T00:00:00Z